Authors:
Driss Boutat
1
;
Mohamed Darouach
2
and
Holger Voos
3
Affiliations:
1
Univ. Orléans and PRISME EA 4229, France
;
2
UHP Nancy I, France
;
3
Université du Luxembourg, Luxembourg
Keyword(s):
Nonlinear Dynamical Systems, Observer Design, Insulin Kinetics.
Related
Ontology
Subjects/Areas/Topics:
Animation and Simulation
;
Biomedical Engineering
;
Biomedical Signal Processing
;
Computer Vision, Visualization and Computer Graphics
;
Detection and Identification
;
Motion Control
Abstract:
This work deals with an observer design for a nonlinear minimal dynamic model of glucose disappearance
and insulin kinetics (GD-IK). At first, the model is transformed into a nonlinear observer normal form. Then,
using the knowledge of the plasma blood glucose level, we estimate the state variables that are not directly
available from the system, i.e. the remote compartment insulin utilization, the plasma insulin deviation and
the infusion rate. In addition, we estimate the amount of absorbed glucose by means of the inverse dynamics.