loading
Papers

Research.Publish.Connect.

Paper

Authors: A. Moita 1 ; C. Caldeira 1 ; F. Jacinto 1 ; R. Lima 2 ; E. Vega 3 and A. Moreira 1

Affiliations: 1 IN+ Center for Innovation, Technology and Policy Research, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal ; 2 CEFT, Faculdade de Engenharia da Universidade do Porto (FEUP), R. Dr. Roberto Frias, 4200-465, Porto, Portugal, Metrics, Mechanical Engineering Department, University of Minho, Campus de Azurém, 4800-058, Guimarães, Portugal ; 3 Área de Mecánica de Fluidos, Dpto. de Ingeniería Mecánica, Energética y de los Materiales, Escuela de Ingenierias Industriales, Universidade de Extremadura, Campus Universitario, Av. de Elvas, s/n, 06006, Badajoz, Spain

ISBN: 978-989-758-353-7

Keyword(s): Lab-on-a-chip, Droplet based Microfluidics, Clinical Diagnostics, Cell Deformability, Bioanalogue Fluid.

Abstract: The present paper addresses the final tests (concerning the transport section) of a microfluidic device to be used in cancer diagnostics, based on the mechanical properties of the cells and particularly on deformability. Following the previous work, which established the materials to be used, according to the wetting properties and their influence on the dynamic response of the droplets (which are electrostatically actuated) this paper presents the final simulations to optimize the thickness and material of the dielectric coating, always as a function of the dynamic response of the droplets. Then, to avoid contamination issues, a number of analogue fluids are proposed, in a new approach, which are characterized and tested in the second part of the work. Regarding the characterization of these new fluids, preliminary results suggest a great potential of a surfactant solution to be used as an analogue. The addition of the surfactant results in the formation of semi-rigid particles with a size distribution and deformation characteristics compatible with those of the biosamples to be studied. The surfactant solution also shows a swift response to electrostatic actuation. (More)

PDF ImageFull Text

Download
CC BY-NC-ND 4.0

Sign In Guest: Register as new SciTePress user now for free.

Sign In SciTePress user: please login.

PDF ImageMy Papers

You are not signed in, therefore limits apply to your IP address 18.208.187.169

In the current month:
Recent papers: 100 available of 100 total
2+ years older papers: 200 available of 200 total

Paper citation in several formats:
Moita, A.; Caldeira, C.; Jacinto, F.; Lima, R.; Vega, E. and Moreira, A. (2019). Cell Deformability Studies for Clinical Diagnostics: Tests with Blood Analogue Fluids using a Drop based Microfluidic Device.In Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES, ISBN 978-989-758-353-7, pages 99-107. DOI: 10.5220/0007578100990107

@conference{biodevices19,
author={A. S. Moita. and C. Caldeira. and F. Jacinto. and R. Lima. and E. J. J. Vega. and A. L. N. Moreira.},
title={Cell Deformability Studies for Clinical Diagnostics: Tests with Blood Analogue Fluids using a Drop based Microfluidic Device},
booktitle={Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES,},
year={2019},
pages={99-107},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007578100990107},
isbn={978-989-758-353-7},
}

TY - CONF

JO - Proceedings of the 12th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 1: BIODEVICES,
TI - Cell Deformability Studies for Clinical Diagnostics: Tests with Blood Analogue Fluids using a Drop based Microfluidic Device
SN - 978-989-758-353-7
AU - Moita, A.
AU - Caldeira, C.
AU - Jacinto, F.
AU - Lima, R.
AU - Vega, E.
AU - Moreira, A.
PY - 2019
SP - 99
EP - 107
DO - 10.5220/0007578100990107

Login or register to post comments.

Comments on this Paper: Be the first to review this paper.