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Authors: Christopher Y. Thang and Paul A. Meehan

Affiliation: The University of Queensland, Australia

ISBN: 978-989-758-069-7

ISSN: 2184-4305

Keyword(s): Closed-loop, Neural Feedback, Adaptive Deep Brain Stimulation, Parkinson’s Disease.

Related Ontology Subjects/Areas/Topics: Applications and Services ; Biomedical Engineering ; Biomedical Signal Processing ; Computer Vision, Visualization and Computer Graphics ; Detection and Identification ; Medical Image Detection, Acquisition, Analysis and Processing ; Physiological Processes and Bio-Signal Modeling, Non-Linear Dynamics

Abstract: Deep Brain Stimulation of the sub-thalamic nucleus (STN) has been proven to be effective at reducing symptoms of patients with Parkinson’s disease (PD). Currently an implanted pulse generator provides chronic electrical stimulation to the STN via an electrode and the stimulation parameters are chosen heuristically. Closed-loop Deep Brain Stimulation (DBS) has been proposed as an improvement to this, utilising neural signal feedback to select stimulation parameters, adjust the duration of stimulation and achieve better patient outcomes more efficiently. In this research, potential neural feedback signals were investigated using a computational simulation of the basal ganglia. It was found that the interspike-interval in the globus pallidus externus provided a possible metric for ‘on’ and ‘off’ states in Parkinson’s disease. This parameter was subsequently implemented as neural feedback in an adaptive closed-loop DBS simulation and was shown to be effective. In particular, the thalamic relaying capability was evaluated using an Error Index (EI) and the adaptive DBS was found to reduce the EI to 2%, which compared with 20% for the PD case without DBS. This was achieved using 58% of the stimulation time used during continuous DBS, indicating a large reduction in DBS energy requirements. This selection and implementation of a potential neural feedback parameter will assist in developing improved implanted DBS pulse generators. (More)


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Paper citation in several formats:
Y. Thang, C. and A. Meehan, P. (2015). Computational Investigation of Adaptive Deep Brain Stimulation.In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2015) ISBN 978-989-758-069-7, pages 66-75. DOI: 10.5220/0005212400660075

author={Christopher {Y. Thang}. and Paul {A. Meehan}.},
title={Computational Investigation of Adaptive Deep Brain Stimulation},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2015)},


JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2015)
TI - Computational Investigation of Adaptive Deep Brain Stimulation
SN - 978-989-758-069-7
AU - Y. Thang, C.
AU - A. Meehan, P.
PY - 2015
SP - 66
EP - 75
DO - 10.5220/0005212400660075

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