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Ontology
Subjects/Areas/Topics:Biological Systems
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Complex Systems Modeling and Simulation
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Fluid Dynamics
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Multiscale Simulation
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Simulation and Modeling

Abstract: In this work the steady-state flow in a commercial dry powder inhaler device (i.e., Turbuhaler) is described. The DPI geometry is constructed in a CAD/CAM environment (i.e., CATIA v5) and then imported into GAMBIT where the geometry is discretized into a computational grid. The Navier-Stokes equations are solved using FLUENT (v6.3) considering different flow models, i.e., laminar, k-ε, k-ε RNG, and k-ω SST. Particle motion and deposition are described using an Eulerian-fluid/Lagrangian-particle approach. Flow and particle deposition for a range of mouthpiece pressure drops (i.e., 800-8800Pa), as well as particle sizes corresponding to single particles and aggregates (i.e., 0.5-20μm) are examined. The total volumetric outflow rate, the overall particle deposition as well as the particle deposition sites in the DPI are determined. The transitional k-ω SST model for turbulent flow was found to produce results most similar to a reference Large Eddy Simulation solution as well as experimental results for the pressure drop in the DPI. Realistic particle deposition results could only be obtained by considering a nonideal sticking coefficient corresponding to a critical capture velocity of 2.7m/s. Overall, the simulation results are found to agree well with available experimental data for volumetric flow and particle deposition.(More)

In this work the steady-state flow in a commercial dry powder inhaler device (i.e., Turbuhaler) is described. The DPI geometry is constructed in a CAD/CAM environment (i.e., CATIA v5) and then imported into GAMBIT where the geometry is discretized into a computational grid. The Navier-Stokes equations are solved using FLUENT (v6.3) considering different flow models, i.e., laminar, k-ε, k-ε RNG, and k-ω SST. Particle motion and deposition are described using an Eulerian-fluid/Lagrangian-particle approach. Flow and particle deposition for a range of mouthpiece pressure drops (i.e., 800-8800Pa), as well as particle sizes corresponding to single particles and aggregates (i.e., 0.5-20μm) are examined. The total volumetric outflow rate, the overall particle deposition as well as the particle deposition sites in the DPI are determined. The transitional k-ω SST model for turbulent flow was found to produce results most similar to a reference Large Eddy Simulation solution as well as experimental results for the pressure drop in the DPI. Realistic particle deposition results could only be obtained by considering a nonideal sticking coefficient corresponding to a critical capture velocity of 2.7m/s. Overall, the simulation results are found to agree well with available experimental data for volumetric flow and particle deposition.

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Milenkovic, J.; H. Alexopoulos, A. and Kiparissides, C. (2012). Airflow and Particle Deposition in a Dry Powder Inhaler - A CFD Simulation.In Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH, ISBN 978-989-8565-20-4, ISSN 2184-2841, pages 250-259. DOI: 10.5220/0004058102500259

@conference{simultech12, author={J. Milenkovic. and A. H. Alexopoulos. and C. Kiparissides.}, title={Airflow and Particle Deposition in a Dry Powder Inhaler - A CFD Simulation}, booktitle={Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH,}, year={2012}, pages={250-259}, publisher={SciTePress}, organization={INSTICC}, doi={10.5220/0004058102500259}, isbn={978-989-8565-20-4}, }

TY - CONF

JO - Proceedings of the 2nd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: SIMULTECH, TI - Airflow and Particle Deposition in a Dry Powder Inhaler - A CFD Simulation SN - 978-989-8565-20-4 AU - Milenkovic, J. AU - H. Alexopoulos, A. AU - Kiparissides, C. PY - 2012 SP - 250 EP - 259 DO - 10.5220/0004058102500259