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Authors: Jungsuk Kim ; Kenneth D. Pedrotti and William B. Dunbar

Affiliation: University of California and Santa Cruz, United States

ISBN: 978-989-8425-91-1

Keyword(s): Patch-clamp Technique, Solid-state Nanopore, Low-noise Biosensor, Single-molecule DNA Analysis.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Instrumentation ; Biomedical Instruments and Devices ; Biomedical Sensors ; Devices ; Health Monitoring Devices ; Human-Computer Interaction ; Low-Power Design ; Microelectronics ; Physiological Computing Systems

Abstract: In this paper, an integrated high-sensitivity patch-clamp sensor is proposed to measure the ultra-low current variation of a solid-state nanopore device. This sensor amplifier consists of three stages: 1) a headstage, 2) a difference amplifier and 3) a unity-gain buffer. For the headstage, a resistive-feedback transimpedance amplifier is employed to convert the small current to a readable voltage. The addition of a programmable gain to the second-stage difference amplifier allows the maximum gain to be increased to 168dBΩ. This sensor is fabricated in a 0.35m CMOS process and is tested with an 80nm-diameter solid-state nanopore. We present a detailed circuit analysis for the low-noise patch-clamp design and its noise measurement result in this paper.

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Paper citation in several formats:
Kim, J.; Pedrotti, K. and Dunbar, W. (2012). A FULLY INTEGRATED CMOS SENSOR FOR PICO-CURRENT MEASUREMENT ON SOLID-STATE NANOPORE DEVICES.In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012) ISBN 978-989-8425-91-1, pages 27-31. DOI: 10.5220/0003732000270031

@conference{biodevices12,
author={Jungsuk Kim. and Kenneth D. Pedrotti. and William B. Dunbar.},
title={A FULLY INTEGRATED CMOS SENSOR FOR PICO-CURRENT MEASUREMENT ON SOLID-STATE NANOPORE DEVICES},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)},
year={2012},
pages={27-31},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003732000270031},
isbn={978-989-8425-91-1},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)
TI - A FULLY INTEGRATED CMOS SENSOR FOR PICO-CURRENT MEASUREMENT ON SOLID-STATE NANOPORE DEVICES
SN - 978-989-8425-91-1
AU - Kim, J.
AU - Pedrotti, K.
AU - Dunbar, W.
PY - 2012
SP - 27
EP - 31
DO - 10.5220/0003732000270031

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