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Authors: Guido Dell'Acqua and Alberto Bersani

Affiliation: Sapienza Università di Roma, Italy

ISBN: 978-989-8425-36-2

Keyword(s): Michaelis-Menten kinetics, Quasi steady-state approximations, Substrate sequestration.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Enterprise Information Systems ; Genomics and Proteomics ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Simulation ; Systems Biology

Abstract: In this paper we discuss the applicability of the standard quasi steady-state approximation (sQSSA) to complex enzyme reaction networks, like the ones involved in intracellular signal transduction. In particular we focus on the dynamics of the intermediate complexes, which in common literature either are ignored or are supposed to rapidly become negligible in the quasi steady-state phase, differently from what really happens. This brings to what we call ”complex depletion paradox”, according to which complexes disappear in the conservation laws, in contrast with the equations of their dynamics. Applying the total quasi steady-state approximation (tQSSA) to the double phosphorylation-dephosphorylation cycle, we show how to solve the apparent paradox, without the need of further hypotheses, like, for example, the substrate sequestration.

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Paper citation in several formats:
Dell'Acqua, G. and Bersani, A. (2011). BISTABILITY AND THE COMPLEX DEPLETION PARADOX IN THE DOUBLE PHOSPHORYLATION-DEPHOSPHORYLATION CYCLE.In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011) ISBN 978-989-8425-36-2, pages 55-65. DOI: 10.5220/0003169800550065

@conference{bioinformatics11,
author={Guido Dell'Acqua. and Alberto Bersani.},
title={BISTABILITY AND THE COMPLEX DEPLETION PARADOX IN THE DOUBLE PHOSPHORYLATION-DEPHOSPHORYLATION CYCLE},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011)},
year={2011},
pages={55-65},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003169800550065},
isbn={978-989-8425-36-2},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011)
TI - BISTABILITY AND THE COMPLEX DEPLETION PARADOX IN THE DOUBLE PHOSPHORYLATION-DEPHOSPHORYLATION CYCLE
SN - 978-989-8425-36-2
AU - Dell'Acqua, G.
AU - Bersani, A.
PY - 2011
SP - 55
EP - 65
DO - 10.5220/0003169800550065

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