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Authors: T. Pinheiro 1 ; C. Ramos 1 ; P. Napoleão 2 ; C. Mendonça 1 ; C. Fondinho 3 ; M. Selas 3 ; M. Mota Carmo 4 and R. Cruz Ferreira 4

Affiliations: 1 Universidade Técnica de Lisboa, Portugal ; 2 Instituto de Medicina Molecular, Portugal ; 3 Hospital de Santa Marta CHLC, Portugal ; 4 Hospital de Santa Marta CHLC and Universidade Nova de Lisboa, Portugal

Keyword(s): Coronary Artery Disease, Atherosclerosis, Vulnerable Plaque Phenotype.

Abstract: The relationship between plaque morphology and clinical presentation was examined. Lumen dimensions, atheroma morphology and composition were assessed by virtual histology intravascular ultrasound (VH-IVUS) in 1757 frames of coronary segments of interest of 17 patients with acute and chronic coronary artery disease, i.e., ST-elevation (STEMI) and non-ST-elevation (NSTEMI) myocardial infarction, unstable angina (UA) and stable angina (SA). Large plaque areas with distended elastic lamina (EEL), rich in fibrotic (FB) and fibro-fatty (FF) tissues associated with STEMI and UA. Variants of this phenotype consisting of large calcium deposits and reduced lumen area were prevalent in NSTEMI patients. SA patients consistently showed plaques with small areas, marked constrictive growth and low FF content. IVUS-derived plaque measures provided phenotypes of vulnerability and rupture that may help improving risk stratification of both symptomatic and asymptomatic patients.

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Paper citation in several formats:
Pinheiro, T.; Ramos, C.; Napoleão, P.; Mendonça, C.; Fondinho, C.; Selas, M.; Mota Carmo, M. and Cruz Ferreira, R. (2013). Plaque Vulnerability Phenotype in Patients with Coronary Artery Disease - An Intravascular Ultrasound Radiofrequency Analysis. In Proceedings of the International Congress on Cardiovascular Technologies (CARDIOTECHNIX 2013) - VisualCardio; ISBN 978-989-8565-78-5, SciTePress, pages 84-89. DOI: 10.5220/0004664400840089

@conference{visualcardio13,
author={T. Pinheiro. and C. Ramos. and P. Napoleão. and C. Mendon\c{C}a. and C. Fondinho. and M. Selas. and M. {Mota Carmo}. and R. {Cruz Ferreira}.},
title={Plaque Vulnerability Phenotype in Patients with Coronary Artery Disease - An Intravascular Ultrasound Radiofrequency Analysis},
booktitle={Proceedings of the International Congress on Cardiovascular Technologies (CARDIOTECHNIX 2013) - VisualCardio},
year={2013},
pages={84-89},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004664400840089},
isbn={978-989-8565-78-5},
}

TY - CONF

JO - Proceedings of the International Congress on Cardiovascular Technologies (CARDIOTECHNIX 2013) - VisualCardio
TI - Plaque Vulnerability Phenotype in Patients with Coronary Artery Disease - An Intravascular Ultrasound Radiofrequency Analysis
SN - 978-989-8565-78-5
AU - Pinheiro, T.
AU - Ramos, C.
AU - Napoleão, P.
AU - Mendonça, C.
AU - Fondinho, C.
AU - Selas, M.
AU - Mota Carmo, M.
AU - Cruz Ferreira, R.
PY - 2013
SP - 84
EP - 89
DO - 10.5220/0004664400840089
PB - SciTePress

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