Authors:
E. D. Gorbunova
1
;
G. N. Bisaga
2
;
A. G. Trufanov
3
;
M. P. Topuzova
2
;
A. G. Fokin
1
;
A. G. Levchuk
1
;
A. Yu. Medenikov
1
;
E. D. Vyshedkevich
1
;
T. A. Bukkieva
1
;
A. G. Efimtsev
1
and
I. A. Mashchenko
1
Affiliations:
1
MRI Department, Almazov National Medical Research Centre, Akkuratova str., 2, Saint-Petersburg, Russian Federation
;
2
Neurology Department, Almazov National Medical Research Centre, Akkuratova str., 2, Saint-Petersburg, Russian Federation
;
3
Neurology Department, Military Medical Academy n.a. S. M. Kirov, Lebedeva str., 6, Saint-Petersburg, Russian Federation
Keyword(s):
Multiple Sclerosis, Morphometry, Voxel-based Morphometry, Autologous Haematopoietic Stem Cell Transplantation.
Abstract:
Correlation analysis of magnetic resonance voxel-based morphometric parameters of patients with multiple
sclerosis before and after high-dose immunosuppressive therapy with transplantation of autologous
hematopoietic stem cells (HDIT + AHSCT). The use of MR-morphometry methods makes it possible to
quantitatively and objectively changes of the volume and size of the structures of the brain and cerebellum in
patients with MS. We observed 10 patients with MS (3 men, 7 women) who underwent HDIT + AHSCT, and
MRI studies were performed before and after transplantation. After postprocessing of MRI data and statistic
analyses of morphometry parameters some changes were accrued: some patients showed negative dynamics
in white and grey mater volumes and decrease of the absolute volume of the thalamus. Also, study showed
positive dynamics in reducing the number of new MS lesions. These results can be associated with the result
of treatment, with a local decrease in edema and inflammati
on. Study showed the need for dynamic MR
control of the grey and white matter of the brain and subcortical structures with the help of MR morphometry.
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