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Authors: Christian Schmidt and Ursula van Rienen

Affiliation: University of Rostock, Germany

ISBN: 978-989-8565-36-5

Keyword(s): Deep Brain Stimulation, Finite Element Method, Fourier Transform.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Signal Processing ; Electromagnetic Fields in Biology and Medicine ; Informatics in Control, Automation and Robotics ; Signal Processing, Sensors, Systems Modeling and Control ; Time and Frequency Response ; Time-Frequency Analysis

Abstract: The objective of this study was to investigate the role of frequency-dependent material properties on the voltage response and neural activation in a volume conductor model for deep brain stimulation (DBS). A finite element model of the brain was developed comprising tissue heterogeneity of gray matter, white matter, and cerebrospinal fluid, which was derived from magnetic resonance images of the SRI24 multi-channel brain atlas. A model of the Medtronic DBS 3387 lead surrounded by an encapsulation layer was positioned in the subthalamic nucleus (STN). The frequency-dependent properties of brain tissue and their single-frequency approximations were modelled as voltage- and current-controlled equivalent circuits. The frequency of best approximation, for which the pulse deviation between the single-frequency and frequency-dependent voltage response were minimal, was computed in a frequency range between 130 Hz and 1:3 MHz. Single-frequency approximations of the DBS pulses and the resulti ng volume of tissue activated (VTA) were found to be in good agreement with the pulses and VTAs obtained from the frequency-dependent solution. Single-frequency approximations were computed by combining finite element method with equivalent circuits. This method allows a fast computation of the time-dependent voltage response in the proximity of the stimulated target by requiring only one finite element computation. (More)

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Paper citation in several formats:
Schmidt, C. and van Rienen, U. (2013). Single Frequency Approximation of Volume Conductor Models for Deep Brain Stimulation using Equivalent Circuits.In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013) ISBN 978-989-8565-36-5, pages 38-47. DOI: 10.5220/0004223700380047

@conference{biosignals13,
author={Christian Schmidt. and Ursula van Rienen.},
title={Single Frequency Approximation of Volume Conductor Models for Deep Brain Stimulation using Equivalent Circuits},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)},
year={2013},
pages={38-47},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004223700380047},
isbn={978-989-8565-36-5},
}

TY - CONF

JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2013)
TI - Single Frequency Approximation of Volume Conductor Models for Deep Brain Stimulation using Equivalent Circuits
SN - 978-989-8565-36-5
AU - Schmidt, C.
AU - van Rienen, U.
PY - 2013
SP - 38
EP - 47
DO - 10.5220/0004223700380047

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