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Authors: Paweł Błażej ; Paweł Mackiewicz ; Małgorzata Wańczyk and Stanisław Cebrat

Affiliation: University of Wrocław, Poland

ISBN: 978-989-8565-35-8

Keyword(s): DNA Asymmetry, Genome Rearrangements, Monte Carlo Simulation, Mutational Pressure.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Enterprise Information Systems ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Sequence Analysis ; Simulation

Abstract: The main force shaping the structure of bacterial chromosomes is the replication-associated mutational pressure which is characterized by distinct nucleotide substitution patterns acting on differently replicated DNA strands (leading and lagging). Therefore, the composition of DNA strands is asymmetric and it is important at which strand a gene is located and into which strand it could be translocated. Thus, the mutational pressure restricts also intragenomic translocations. To analyze this effect, we have elaborated a simulation model of bacterial genome evolution assuming translocation of protein coding genes and different types of selection acting on their sequences. The ’negative’ selection eliminated individuals if the coding signal of any gene in its genome dropped below the acceptable range, whereas the ’stabilizing’ selection did not allow for the decrease in the coding signal of any gene below its original value. Under the ’negative’ selection more genes stayed or were transl ocated to the lagging strand, whereas under the ’stabilizing’ selection more genes preferred the leading strand. The ’stabilizing’ selection eliminated more individuals because of the coding signal loss and slightly fewer because of the stop codon generation. The ’stabilizing’ selection allowed also for much less gene translocations between strands than the ’negative’ selection. (More)

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Paper citation in several formats:
Błażej, P.; Błażej, P.; Mackiewicz, P.; Wańczyk, M. and Cebrat, S. (2013). Evolution of Bacterial Genome under Changing Mutational Pressure - Computer Simulation Studies.In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013) ISBN 978-989-8565-35-8, pages 272-277. DOI: 10.5220/0004192802720277

@conference{bioinformatics13,
author={Paweł Błażej. and Paweł Błażej. and Paweł Mackiewicz. and Małgorzata Wańczyk. and Stanisław Cebrat.},
title={Evolution of Bacterial Genome under Changing Mutational Pressure - Computer Simulation Studies},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)},
year={2013},
pages={272-277},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004192802720277},
isbn={978-989-8565-35-8},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)
TI - Evolution of Bacterial Genome under Changing Mutational Pressure - Computer Simulation Studies
SN - 978-989-8565-35-8
AU - Błażej, P.
AU - Błażej, P.
AU - Mackiewicz, P.
AU - Wańczyk, M.
AU - Cebrat, S.
PY - 2013
SP - 272
EP - 277
DO - 10.5220/0004192802720277

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