Author:
Irma Yanti Rangkuti
Affiliation:
Biomedic/Pharmacology Department, Faculty of Medicine, Universitas Islam Sumatera Utara, Indonesia
Keyword(s):
Paclitaxel, doxorubicin, cytotoxicity, T47D breast cancer cell.
Abstract:
Breast cancer is a type of cancer commonly found by most women, ranking fifth leading cause of cancer
worldwide cancer, consist of various subtypes. Chemotherapy is one of therapy in breast cancer patients but
the benefit is not equal for all patients and paclitaxel is one of the most important chemotherapeutic drugs.
The descriptive study had been done to paclitaxel and doxorubicin in T47D breast cancer cell. This study
aimed to compare cytotoxic effect of paclitaxel and doxorubicin in T47D breast cancer cell, used paclitaxel
concentrations 1000; 500; 250; 31,25; 15,625 nM and doxorubicin concentrations 500; 250;62,5;31,25;and
15,625 nM for 24 hours. This study was an invitro. The cytotoxic test used MTT method to determine IC50
and analized by SPSS. The result showed that IC50 paclitaxel was 1577,2 ± 115,3 nM and IC50 doxorubicin
202,37 ± 3,99 nM. The cytotoxicity of paclitaxel was smaller than doxorubicin in T47D breast cancer cell.