Authors:
Santa Di Cataldo
;
Elisa Ficarra
and
Enrico Macii
Affiliation:
Politecnico di Torino, Italy
Keyword(s):
Tissue segmentation, tissue confocal images, immunohistochemistry, K-means clustering, Support Vector Machine.
Related
Ontology
Subjects/Areas/Topics:
Applications and Services
;
Artificial Intelligence
;
Biomedical Engineering
;
Biomedical Signal Processing
;
Computer Vision, Visualization and Computer Graphics
;
Data Manipulation
;
Health Engineering and Technology Applications
;
Human-Computer Interaction
;
Medical Image Detection, Acquisition, Analysis and Processing
;
Methodologies and Methods
;
Neurocomputing
;
Neurotechnology, Electronics and Informatics
;
Pattern Recognition
;
Physiological Computing Systems
;
Sensor Networks
;
Soft Computing
Abstract:
In this paper we present a fully-automated method for the detection of tumor areas in immunohistochemical confocal images. The image segmentation provided by the proposed technique allows quantitative protein activity evaluation on the target tumoral tissue disregarding tissue areas that are not affected by the pathology, such as connective tissue. The automated method, that is based on an innovative unsupervised clustering approach, enables more accurate tissue segmentation compared to traditional supervised methods that can be found in literature, such as Support Vector Machine (SVM). Experimental results conducted on a large set of heterogeneous immunohistochemical lung cancer tissue images demonstrate that the proposed approach overcomes the performance of SVM by 8%, achieving on average an accuracy of 90%.