Authors:
Francisco Franco-Martínez
1
;
William Solórzano-Requejo
2
;
1
;
Alejandro de Blas-de Miguel
1
;
Matthias Vostatek
3
;
Christian Grasl
3
;
4
;
Marta Bonora
3
;
Francesco Moscato
3
;
4
;
5
and
Andrés Díaz Lantada
1
Affiliations:
1
ETSI Industriales, Universidad Politécnica de Madrid, Madrid, Spain
;
2
Department of Mechanical and Electrical Engineering, Universidad de Piura, Piura, Peru
;
3
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
;
4
Ludwig Boltzmann Institute for Cardiovascular Research, Vienna, Austria
;
5
Austrian Cluster for Tissue Regeneration, Vienna, Austria
Keyword(s):
Metasurfaces, Metamaterials, Additive Manufacturing, Coronary Artery Disease, Personalized Medicine.
Abstract:
Currently, the most usual treatment for coronary artery disease is the use of stents, which are produced with standard dimensions and shapes and the surgeon selects the one that best fits the patient’s anatomy. Due to this treatment, likelihood of restenosis might reach 40%. Additionally, thrombi formation is an important risk for these patients that is treated with anticoagulant medicines. Therefore, a design and manufacturing method to produce microtextured patient-specific coronary stent is developed with the aim to minimize the likelihood of restenosis and thrombosis. Stents consisting of unit cells structures that are regularly repeated to form a ring and, sometimes connectors to join the rings. To improve the fitting between artery and stent, parametric design of unit cell as a function of the length and mean radius of coronary artery is required. Then, the unit cell is microtextured to improve hemocompatibility using a bioinspired design in shark skin, which provide superhydro
phobicity, drag reduction and oleophobicity under water conditions. Once the unit cell is micropatterned, a reverse engineering reconstruction is done to obtain the stent model. Finally, the design is manufactured with a 3D printer using two-photon polymerisation technology. SEM is used to evaluate the design and manufacturing method.
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