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Authors: Karine Charrière 1 ; Jean Sebastien Guerrini-Chappuis 1 ; Bruno Wacogne 2 ; Alain Rouleau 3 ; Celine Elie-Caille 3 ; Christian Pieralli 3 ; Lionel Pazart 1 ; Pascal Morel 4 and Wilfrid Boireau 3

Affiliations: 1 Besançon University Hospital, France ; 2 Besançon University Hospital and University of Franche-Comté, France ; 3 University of Franche-Comté, France ; 4 French Blood Transfusion Center, France

ISBN: 978-989-8425-91-1

Keyword(s): Blood transfusion, Lab-on-chip, Microarray, Nanobiotechnology, Surface functionalization, Biosensor, Bedside test, ABO compatibility, Crossmatch.

Related Ontology Subjects/Areas/Topics: Biocomputing and Biochips ; Biomedical Engineering ; Biomedical Instruments and Devices ; Biomedical Sensors

Abstract: Before each transfusion of red blood cell concentrate, a final ABO compatibility test is carried out at the patient's bedside on a piece of card and interpreted visually. Despite this ultimate test, transfusion accidents still occur due to group incompatibility, which can be lethal. In order to improve this test, we have developed a specific device based on microarrays for the validation of a smart and safe transfuser in the context of critical transfusional situations. This miniaturized device incorporates a biochip to analyze ABO compatibility in order that the hemagglutination reaction of red blood cells with IgMs in solution be replaced by specific capture and concentration of IgMs on microarrays. Results indicate that a specific immunocapture is obtained with globular concentrates and with different total blood. Smarttransfuser is a smart device developed in collaboration with the French Blood Transfusion Center for the optimization at the patient’s bedside of an ultimate test pr ior to transfusion. (More)

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Paper citation in several formats:
Charrière, K.; Sebastien Guerrini-Chappuis, J.; Wacogne, B.; Rouleau, A.; Elie-Caille, C.; Pieralli, C.; Pazart, L.; Morel, P. and Boireau, W. (2012). SmarTTransfuser - A Biochip System for the Final ABO Compatibility Test.In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012) ISBN 978-989-8425-91-1, pages 257-262. DOI: 10.5220/0003852402570262

@conference{biodevices12,
author={Karine Charrière. and Jean Sebastien Guerrini{-}Chappuis. and Bruno Wacogne. and Alain Rouleau. and Celine Elie{-}Caille. and Christian Pieralli. and Lionel Pazart. and Pascal Morel. and Wilfrid Boireau.},
title={SmarTTransfuser - A Biochip System for the Final ABO Compatibility Test},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)},
year={2012},
pages={257-262},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003852402570262},
isbn={978-989-8425-91-1},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2012)
TI - SmarTTransfuser - A Biochip System for the Final ABO Compatibility Test
SN - 978-989-8425-91-1
AU - Charrière, K.
AU - Sebastien Guerrini-Chappuis, J.
AU - Wacogne, B.
AU - Rouleau, A.
AU - Elie-Caille, C.
AU - Pieralli, C.
AU - Pazart, L.
AU - Morel, P.
AU - Boireau, W.
PY - 2012
SP - 257
EP - 262
DO - 10.5220/0003852402570262

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