Authors:
Heru Sasongko
;
Diah Pratiwi
;
Trias Amartiwi
;
Nur Rohman Efendi
and
Sugiyarto
Affiliation:
Universitas Sebelas Maret, Indonesia
Keyword(s):
acetaminophen, hepatoprotective, mountain papaya, flavonoid, Vasconcellea pubescens
Abstract:
The liver is a main organ of drugs metabolism in humans. Many studies have reported that acetaminophen has an effect on liver injury. Targeting mitochondrial oxidant stress is a promising therapeutic option for acetaminophen hepatotoxicity. Previous study has shown that mountain papaya (Vasconcellea pubescens A.DC.) fruit has an effect against lipid peroxidation activity. This research aims to know the hepatoprotective effect of mountain papaya fruit ethanolic extract (MPFE) in rats after induced by acetaminophen. The rats were divided into six groups, with group I not administered with any treatment, group II administered with suspension of 0.25% CMC-Na as negative control, group III was administered with suspension of silymarin as positive control. Groups IV, V, and VI were given MPFE with variation doses 120; 240 and 480 mg/kg body weight for 14 days. At day 14th, all groups except the normal group were induced with acetaminophen in toxic dose (2 g/kg body weight). The liver injur
y was measured by ALT, AST, bilirubin, ALP value and liver histology profile. The results showed that MPFE could significantly decrease liver cell injury (p <0.05)
by ALT, AST and liver histology profile parameters in which each dose has the same ability.
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