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Authors: Jorge Guerrero 1 ; Roberto Ambrosio 2 and Amanda Carrillo 1

Affiliations: 1 Universidad Autonoma de Ciudad Juárez, Mexico ; 2 Universidad Autonoma de Ciudad Juarez, Mexico

ISBN: 978-989-758-071-0

Keyword(s): Biosensor, EnFET, Transducer, Myelin Basic Protein, Multiple Sclerosis.

Related Ontology Subjects/Areas/Topics: Biomaterials ; Biomedical Engineering ; Biomedical Instruments and Devices ; Biomedical Sensors ; Microelectronics

Abstract: In this work, the design of a biosensor based on FET technology have been proposed, simulating the modification to the gate of an Ion Sensitive Field-Effect Transistor (ISFET) with a synthetic polymer to entrap the desired analyte which contains Myelin Basic Protein (MBP). This analyte is generally used in test to find out if someone is suffering a demyelinating disease, and is commonly detected by Enzyme Linked Immunosorbent Assays (ELISA). Based on this principle, we propose a simpler method, fundamented on Enzyme Field-Effect Transistor (EnFET) technology in order to develop a new device applied to the diagnosis of demyelinating diseases. Simulation examples are used in order to demonstrate the functionality for this type of biosensor to its exposure to MBP at concentrations of 10-4 to 10-1 mol/L, where the amount of analyte in the receptor located at the top of the gate will determine the level of voltage applied to create a channel and activate the device.

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Paper citation in several formats:
Guerrero, J.; Ambrosio, R. and Carrillo, A. (2015). Design of a Myelin Basic Protein Biosensor based on EnFET Technology.In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015) ISBN 978-989-758-071-0, pages 78-82. DOI: 10.5220/0005180700780082

@conference{biodevices15,
author={Jorge Guerrero. and Roberto Ambrosio. and Amanda Carrillo.},
title={Design of a Myelin Basic Protein Biosensor based on EnFET Technology},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)},
year={2015},
pages={78-82},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005180700780082},
isbn={978-989-758-071-0},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)
TI - Design of a Myelin Basic Protein Biosensor based on EnFET Technology
SN - 978-989-758-071-0
AU - Guerrero, J.
AU - Ambrosio, R.
AU - Carrillo, A.
PY - 2015
SP - 78
EP - 82
DO - 10.5220/0005180700780082

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