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Authors: Malgorzata Kardynska 1 ; Jaroslaw Smieja 1 ; Anna Naumowicz 1 ; Patryk Janus 2 ; Piotr Widlak 2 and Marek Kimmel 3

Affiliations: 1 Silesian University of Technology, Poland ; 2 Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Poland ; 3 Silesian University of Technology and Rice University, Poland

ISBN: 978-989-758-170-0

Keyword(s): Sensitivity Analysis, Sloppy Parameters, Signalling Pathways, NF-кB, HSF, HSP.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Enterprise Information Systems ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Simulation ; Systems Biology

Abstract: Sensitivity analysis methods have been developed for over half a century. However, their application to systems biology is a relatively new concept and has not been fully investigated. In this paperwe focus on creating parameter rankings based on sloppy/stiff parameter sensitivity analysis, that can be used to find the most important parameters and processes (that have the greatest impact on the system output) and subsequently can be used to reduce the number of experiments needed to precisely estimate parameters values or to indicate molecular targets for new drugs. In order to test the proposed procedure we performed sensitivity analysis of the HSF/NF-кB pathway model - a model combining two signaling pathways essential for cell survival.

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Paper citation in several formats:
Kardynska, M.; Smieja, J.; Naumowicz, A.; Janus, P.; Widlak, P. and Kimmel, M. (2016). Sloppy/Stiff Parameters Rankings in Sensitivity Analysis of Signaling Pathways.In Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS, (BIOSTEC 2016) ISBN 978-989-758-170-0, pages 278-283. DOI: 10.5220/0005820002780283

@conference{bioinformatics16,
author={Malgorzata Kardynska. and Jaroslaw Smieja. and Anna Naumowicz. and Patryk Janus. and Piotr Widlak. and Marek Kimmel.},
title={Sloppy/Stiff Parameters Rankings in Sensitivity Analysis of Signaling Pathways},
booktitle={Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS, (BIOSTEC 2016)},
year={2016},
pages={278-283},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005820002780283},
isbn={978-989-758-170-0},
}

TY - CONF

JO - Proceedings of the 9th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS, (BIOSTEC 2016)
TI - Sloppy/Stiff Parameters Rankings in Sensitivity Analysis of Signaling Pathways
SN - 978-989-758-170-0
AU - Kardynska, M.
AU - Smieja, J.
AU - Naumowicz, A.
AU - Janus, P.
AU - Widlak, P.
AU - Kimmel, M.
PY - 2016
SP - 278
EP - 283
DO - 10.5220/0005820002780283

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