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Authors: Jan Schier 1 ; Bohumil Kovár 2 and Eduard Kocárek 3

Affiliations: 1 Institute of Information Theory and Automation of the ASCR, Czech Republic ; 2 Institute of Information Theory and Automation of the ASCR and Czech Technical University in Prague, Czech Republic ; 3 Charles University Prague, Czech Republic

Keyword(s): FISH analysis, Fluorescence microscopy, Image analysis, Image segmentation.

Related Ontology Subjects/Areas/Topics: Algorithms and Software Tools ; Bioinformatics ; Biomedical Engineering ; Image Analysis ; Pattern Recognition, Clustering and Classification

Abstract: The fluorescence in-situ hybridization (FISH) belongs to the most common cytogenetic methods and is widely applied in routine clinical genetic diagnostics. We are paying attention to FISH analysis of chromosomal aneuploidies – the deviations from chromosomal number. Such analysis is based on evaluation of up to several hundreds of microscopic images. Computer support for this process includes using methods of image processing and data mining. In this paper, we focus on the image processing part in more detail: first, the properties of FISH images are reviewed, then, the processing flow is outlined. Our aim is to find the interphase and metaphase nuclei and the hybridization signals contained in the image. A simple method using the raw and central moments of detected objects as measures to distinguish between the two types of nuclei is proposed.

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Paper citation in several formats:
Schier, J.; Kovár, B. and Kocárek, E. (2012). AUTOMATED DETECTION OF INTERPHASE AND METAPHASE NUCLEI IN THE FISH IMAGES. In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2012) - BIOINFORMATICS; ISBN 978-989-8425-90-4; ISSN 2184-4305, SciTePress, pages 347-350. DOI: 10.5220/0003797703470350

@conference{bioinformatics12,
author={Jan Schier. and Bohumil Kovár. and Eduard Kocárek.},
title={AUTOMATED DETECTION OF INTERPHASE AND METAPHASE NUCLEI IN THE FISH IMAGES},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2012) - BIOINFORMATICS},
year={2012},
pages={347-350},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003797703470350},
isbn={978-989-8425-90-4},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2012) - BIOINFORMATICS
TI - AUTOMATED DETECTION OF INTERPHASE AND METAPHASE NUCLEI IN THE FISH IMAGES
SN - 978-989-8425-90-4
IS - 2184-4305
AU - Schier, J.
AU - Kovár, B.
AU - Kocárek, E.
PY - 2012
SP - 347
EP - 350
DO - 10.5220/0003797703470350
PB - SciTePress

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