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Authors: Peiyi Song ; Danny Jian Hang Tng ; Rui Hu and Ken-Tye Yong

Affiliation: Nanyang Technological University, Singapore

ISBN: 978-989-758-071-0

Keyword(s): Cancer Drug Delivery, Implantable Device, Biocompatibility, in Vitro, in Vivo.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Instrumentation ; Biomedical Instruments and Devices ; Hardware ; Implantable Electronics ; MEMS ; Microelectronics ; Sensor Networks

Abstract: Cancer patients nowadays suffer from serious side effects and unpleasant experiences when treated with anti-cancer drugs. Conventional drug delivery methods including drug pills/capsules, topical drug gels/drops and drug injections are too simple, incapable of providing controllable and efficient tumour drug delivery in cancer treatment. Implantable drug delivery devices open a new horizon for drug treatment. Through device implantation locally onto disease site, high efficiency drug delivery can be achieved. Utilizing techniques from microfluidics, precise manipulation of drug fluids by these devices offer great advances for treatment. In our study, an electrochemical actuated microfluidic drug delivery device was fabricated and studied in vitro and in vivo. Cultured pancreatic cancer cell colonies were successfully inhibited by programmable Doxorubicin treatments controlled by devices. Further, 12 devices were implanted into 12 Kunming mice for evaluation of biocompatibility and dru g delivery performance. Tissue biopsy and blood sample analyses indicated all 12 mice remaining healthy after devices implantation. Adrenaline was delivered to the abdominal cavity of the mice by using the implanted device and compared with conventional injection as a positive control. Both approaches have shown that they are able to precisely control and manipulate the increment rate of blood pressure in the small animals. (More)

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Paper citation in several formats:
Song, P.; Tng, D.; Hu, R. and Yong, K. (2015). Engineering Implantable Microfluidic Drug Delivery Device for Individualized Cancer Chemotherapy.In Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015) ISBN 978-989-758-071-0, pages 37-43. DOI: 10.5220/0005202900370043

@conference{biodevices15,
author={Peiyi Song. and Danny Jian Hang Tng. and Rui Hu. and Ken{-}Tye Yong.},
title={Engineering Implantable Microfluidic Drug Delivery Device for Individualized Cancer Chemotherapy},
booktitle={Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)},
year={2015},
pages={37-43},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0005202900370043},
isbn={978-989-758-071-0},
}

TY - CONF

JO - Proceedings of the International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2015)
TI - Engineering Implantable Microfluidic Drug Delivery Device for Individualized Cancer Chemotherapy
SN - 978-989-758-071-0
AU - Song, P.
AU - Tng, D.
AU - Hu, R.
AU - Yong, K.
PY - 2015
SP - 37
EP - 43
DO - 10.5220/0005202900370043

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