Authors:
Dedy Syahrizal
1
;
Ghalia Mayuna
1
and
Teuku Mamfaluti
2
Affiliations:
1
Department of Biochemistry, Faculty of Medicine Universitas Syiah Kuala, Indonesia
;
2
Department of Internal Medicine, Faculty of Medicine Universitas Syiah Kuala-Rumah Sakit Umum Daerah Dr. Zainoel Abidin, Banda Aceh, Indonesia, Indonesia
Keyword(s):
Pare (Momordica charantia L), Hyperglycemia, Blood glucose
Abstract:
Pare (Momordica charantia L.) is one of the traditional herbal plants used to cure several diseases, one of which is to decrease the blood glucose level. This research aims to examine the effectiveness of the ethanol extract in pare to decrease blood glucose level on male Wistar rat (Rattus norvegicus). This was an experimental research which used experimental animals with pretest-posttest control group design. The sample of this research were 40 male mice (Rattus norvegicus)which were divided randomly into 5 groups of treatment; 2 groups were control groups and 3 groups were given pare extract. All of the male mice were induced by 10% glucose solution to increase their blood glucose level. In order to examine the response, the level blood glucose was observed in 30 minutes, 65 minutes, 95 minutes, 125 minutes, and 155 minutes after the glucose induction. The result of blood glucose level was analyzed using the Anova test and Duncan test. The result of this study shows that pare ex
tract with 200mg/kgBB group, compared to other dose level, had faster onset to decrease the blood glucose level of the male Wistar mice that was induced by 10% glucose solution. In conclusion, pare extract effectively decreases the blood glucose level in the glucose-induced male mice.
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