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Authors: J. S. Hallinan ; A. Wipat and S. Park

Affiliation: Newcastle University, United Kingdom

ISBN: 978-989-8425-90-4

Keyword(s): Synthetic biology, Evolutionary computation, Directed evolution, Genome-scale design.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Biostatistics and Stochastic Models ; Computational Intelligence ; Data Mining and Machine Learning ; Enterprise Information Systems ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Simulation ; Soft Computing

Abstract: Computational design is essential to the field of synthetic biology, particularly as its practitioners become more ambitious, and system designs become larger and more complex. However, computational models derived from abstract designs are unlikely to behave in the same way as organisms engineered from those same designs. We propose an automated, iterative strategy involving evolution both in silico and in vivo, with feedback between strands as necessary, combined with automated reasoning. This system can help bridge the gap between the behaviour of computational models and that of engineered organisms in as rapid and cost-effective a manner as possible.

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Paper citation in several formats:
S. Hallinan, J.; Park, S. and Wipat, A. (2012). BRIDGING THE GAP BETWEEN DESIGN AND REALITY - A Dual Evolutionary Strategy for the Design of Synthetic Genetic Circuits.In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012) ISBN 978-989-8425-90-4, pages 263-268. DOI: 10.5220/0003887002630268

@conference{bioinformatics12,
author={J. S. Hallinan. and S. Park. and A. Wipat.},
title={BRIDGING THE GAP BETWEEN DESIGN AND REALITY - A Dual Evolutionary Strategy for the Design of Synthetic Genetic Circuits},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012)},
year={2012},
pages={263-268},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003887002630268},
isbn={978-989-8425-90-4},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012)
TI - BRIDGING THE GAP BETWEEN DESIGN AND REALITY - A Dual Evolutionary Strategy for the Design of Synthetic Genetic Circuits
SN - 978-989-8425-90-4
AU - S. Hallinan, J.
AU - Park, S.
AU - Wipat, A.
PY - 2012
SP - 263
EP - 268
DO - 10.5220/0003887002630268

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