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Authors: Vincenzo Manca and Luca Marchetti

Affiliation: University of Verona, Italy

ISBN: 978-989-8425-89-8

Keyword(s): Biomathematical discrete modelling, Systems biology, Metabolic P Systems.

Related Ontology Subjects/Areas/Topics: Applications and Services ; Biomedical Engineering ; Biomedical Signal Processing ; Computer Vision, Visualization and Computer Graphics ; Medical Image Detection, Acquisition, Analysis and Processing ; Physiological Processes and Bio-Signal Modeling, Non-Linear Dynamics

Abstract: The main framework analysis for the most part of biological dynamics remains the theory of ordinary differential equations (ODEs). However, ODEs present some intrinsic limitations in the evaluation of the kinetic reaction rates. In contrast to ODEs, Metabolic P systems (MP systems), based on P˘aun’s P systems, were introduced for modelling metabolic systems by means of suitable multiset rewriting grammars. In this work three applications of MP systems are presented, for discovering the internal regulation logic of three phenomena relevant in systems biology: i) the Goldbeter’s mitotic oscillator; ii) the glucose/insulin dynamics in the Intravenous Glucose Tolerance Test; iii) the HER-2 oncogene-regulated transcriptome in human SUM-225 cells. Despite the differences between the considered phenomena, in all the cases a model was found that exhibits good approximation of the observed time series and highlights results which are new or that have been only theorized before.

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Paper citation in several formats:
Manca, V. and Marchetti, L. (2012). APPLICATION OF THE MP THEORY TO SYSTEMS BIOLOGY.In Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2012) ISBN 978-989-8425-89-8, pages 303-308. DOI: 10.5220/0003852003030308

@conference{biosignals12,
author={Vincenzo Manca. and Luca Marchetti.},
title={APPLICATION OF THE MP THEORY TO SYSTEMS BIOLOGY},
booktitle={Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2012)},
year={2012},
pages={303-308},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003852003030308},
isbn={978-989-8425-89-8},
}

TY - CONF

JO - Proceedings of the International Conference on Bio-inspired Systems and Signal Processing - Volume 1: BIOSIGNALS, (BIOSTEC 2012)
TI - APPLICATION OF THE MP THEORY TO SYSTEMS BIOLOGY
SN - 978-989-8425-89-8
AU - Manca, V.
AU - Marchetti, L.
PY - 2012
SP - 303
EP - 308
DO - 10.5220/0003852003030308

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