loading
Documents

Research.Publish.Connect.

Paper

Paper Unlock

Authors: Ruben Acuña 1 ; Zoé Lacroix 1 ; Fayez Hadji 2 ; Jacques Chomilier 3 and Nikolaos Papandreou 4

Affiliations: 1 Arizona State University, United States ; 2 Université Pierre et Marie Curie, France ; 3 Université Pierre et Marie Curie and Ressource Parisienne en Bioinformatique Structurale, France ; 4 Agricultural University of Athens, Greece

ISBN: 978-989-8425-90-4

Keyword(s): Chimeric Proteins, Folding, Prediction, Simulation, Fusion Proteins, MIR.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Enterprise Information Systems ; Genomics and Proteomics ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Sequence Analysis ; Simulation ; Structural Variations ; Structure Prediction

Abstract: We propose two computational methods for predicting if a protein produced by fusion of genes will conserve the structures of the fused proteins. We use two complementary paths for prediction. The former is a simulation from the sequence while the latter exploits its expected structure. Early stages of protein folding are simulated from their amino acid sequence by capturing the most interacting residues (MIR). Individual domain structures (or models) are superposed onto the predicted complex structure (or model). When no structure exists, a model is calculated using a set of ab initio and fold recognition tools. These results are used to predict the validity of the chimeric protein. We test the two methods against a dataset of 10 proteins.

PDF ImageFull Text

Download
CC BY-NC-ND 4.0

Sign In Guest: Register as new SciTePress user now for free.

Sign In SciTePress user: please login.

PDF ImageMy Papers

You are not signed in, therefore limits apply to your IP address 35.171.146.16

In the current month:
Recent papers: 100 available of 100 total
2+ years older papers: 200 available of 200 total

Paper citation in several formats:
Acuña, R.; Lacroix, Z.; Hadji, F.; Chomilier, J. and Papandreou, N. (2012). PREDICTION OF CHIMERIC PROTEIN FOLD.In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012) ISBN 978-989-8425-90-4, pages 234-239. DOI: 10.5220/0003790102340239

@conference{bioinformatics12,
author={Ruben Acuña. and Zoé Lacroix. and Fayez Hadji. and Jacques Chomilier. and Nikolaos Papandreou.},
title={PREDICTION OF CHIMERIC PROTEIN FOLD},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012)},
year={2012},
pages={234-239},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003790102340239},
isbn={978-989-8425-90-4},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2012)
TI - PREDICTION OF CHIMERIC PROTEIN FOLD
SN - 978-989-8425-90-4
AU - Acuña, R.
AU - Lacroix, Z.
AU - Hadji, F.
AU - Chomilier, J.
AU - Papandreou, N.
PY - 2012
SP - 234
EP - 239
DO - 10.5220/0003790102340239

Login or register to post comments.

Comments on this Paper: Be the first to review this paper.