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Authors: Ming Li 1 ; Zhong-Can Ou-Yang 2 and Yao-Gen Shu 3

Affiliations: 1 University of Chinese Academy of Sciences, China ; 2 Institute of Theoretical Physics and Chinese Academy of Sciences, China ; 3 University of Chinese Academy of Sciences, Institute of Theoretical Physics and Chinese Academy of Sciences, China

ISBN: 978-989-758-280-6

ISSN: 2184-4305

Keyword(s): Biodevice, DNA Polymerase, Fidelity, 1st-order Terminal Effects.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Biostatistics and Stochastic Models

Abstract: We proposed a comprehensive kinetic model of steady-state copolymerization and obtain analytical solution of the high replication fidelity of the biodevice DNA polymerase. Our analytical calculations definitively show that the neighbor effects are the key factor of the overall fidelity. These analytical results were further demonstrated by T7 DNAp whose fidelity (106) is well described by the 1st-order neighbor effect.

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Paper citation in several formats:
Li, M.; Ou-Yang, Z. and Shu, Y. (2018). Study on the Fidelity of Biodevice T7 DNA Polymerase.In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS, ISBN 978-989-758-280-6, ISSN 2184-4305, pages 135-139. DOI: 10.5220/0006636101350139

@conference{bioinformatics18,
author={Ming Li. and Zhong{-}Can Ou{-}Yang. and Yao{-}Gen Shu.},
title={Study on the Fidelity of Biodevice T7 DNA Polymerase},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS,},
year={2018},
pages={135-139},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006636101350139},
isbn={978-989-758-280-6},
}

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS,
TI - Study on the Fidelity of Biodevice T7 DNA Polymerase
SN - 978-989-758-280-6
AU - Li, M.
AU - Ou-Yang, Z.
AU - Shu, Y.
PY - 2018
SP - 135
EP - 139
DO - 10.5220/0006636101350139

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