Deep-Learning-based Segmentation of Organs-at-Risk in the Head for MR-assisted Radiation Therapy Planning

László Ruskó; Marta E. Capala; Vanda Czipczer; Bernadett Kolozsvári; Borbála Deák-Karancsi; Renáta Czabány; Bence Gyalai; Tao Tan; Zoltán Végváry; Emőke Borzasi; Zsófia Együd; Renáta Kószó; Viktor Paczona; Emese Fodor; Chad Bobb; Cristina Cozzini; Sandeep Kaushik; Barbara Darázs; Gerda M. Verduijn; Rachel Pearson; Ross Maxwell; Hazel Mccallum; Juan A. Hernandez Tamames; Katalin Hideghéty; Steven F. Petit; Florian Wiesinger

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Paper

Deep-Learning-based Segmentation of Organs-at-Risk in the Head for MR-assisted Radiation Therapy Planning

Topics: Applications of Machine Learning; Deep Learning in Bioimaging; Image Processing Methods; Magnetic Resonance Imaging (MRI); Medical Imaging and Diagnosis

In Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 2: BIOSTEC, 31-43, 2021

Authors: László Ruskó ¹ ; Marta E. Capala ² ; Vanda Czipczer ¹ ; Bernadett Kolozsvári ¹ ; Borbála Deák-Karancsi ¹ ; Renáta Czabány ³ ; Bence Gyalai ³ ; Tao Tan ¹ ; Zoltán Végváry ⁴ ; Emőke Borzasi ⁴ ; Zsófia Együd ⁴ ; Renáta Kószó ⁴ ; Viktor Paczona ⁴ ; Emese Fodor ⁴ ; Chad Bobb ⁵ ; Cristina Cozzini ⁶ ; Sandeep Kaushik ⁶ ; Barbara Darázs ³ ; Gerda M. Verduijn ² ; Rachel Pearson ⁷ ; Ross Maxwell ⁷ ; Hazel Mccallum ⁷ ; Juan A. Hernandez Tamames ⁸ ; Katalin Hideghéty ⁴ ; Steven F. Petit ² and Florian Wiesinger ⁶

Affiliations: ¹ GE Healthcare, Budapest, Hungary ; ² Erasmus MC Cancer Institute, Department of Radiation Oncology, Rotterdam, The Netherlands ; ³ GE Healthcare, Szeged, Hungary ; ⁴ University of Szeged, Department of Oncotherapy, Szeged, Hungary ; ⁵ GE Healthcare, Milwaukee, U.S.A. ; ⁶ GE Healthcare, Munich, Germany ; ⁷ Newcastle University, Northern Institute for Cancer Research, Newcastle, U.K. ; ⁸ Erasmus MC, Department of Radiology and Nuclear Medicine, Rotterdam, The Netherlands

Keyword(s): Organ-at-Risk, Head, Radiation Therapy, MRI, Segmentation, Deep Learning, U-Net.

Abstract: Segmentation of organs-at-risk (OAR) in MR images has several clinical applications; including radiation therapy (RT) planning. This paper presents a deep-learning-based method to segment 15 structures in the head region. The proposed method first applies 2D U-Net models to each of the three planes (axial, coronal, sagittal) to roughly segment the structure. Then, the results of the 2D models are combined into a fused prediction to localize the 3D bounding box of the structure. Finally, a 3D U-Net is applied to the volume of the bounding box to determine the precise contour of the structure. The model was trained on a public dataset and evaluated on both public and private datasets that contain T2-weighted MR scans of the head-and-neck region. For all cases the contour of each structure was defined by operators trained by expert clinical delineators. The evaluation demonstrated that various structures can be accurately and efficiently localized and segmented using the prese nted framework. The contours generated by the proposed method were also qualitatively evaluated. The majority (92%) of the segmented OARs was rated as clinically useful for radiation therapy. (More)

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Ruskó, L.; Capala, M.; Czipczer, V.; Kolozsvári, B.; Deák-Karancsi, B.; Czabány, R.; Gyalai, B.; Tan, T.; Végváry, Z.; Borzasi, E.; Együd, Z.; Kószó, R.; Paczona, V.; Fodor, E.; Bobb, C.; Cozzini, C.; Kaushik, S.; Darázs, B.; Verduijn, G.; Pearson, R.; Maxwell, R.; Mccallum, H.; Hernandez Tamames, J.; Hideghéty, K.; Petit, S. and Wiesinger, F. (2021). Deep-Learning-based Segmentation of Organs-at-Risk in the Head for MR-assisted Radiation Therapy Planning. In Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - BIOIMAGING; ISBN 978-989-758-490-9; ISSN 2184-4305, SciTePress, pages 31-43. DOI: 10.5220/0010235000002865

@conference{bioimaging21,
author={László Ruskó. and Marta E. Capala. and Vanda Czipczer. and Bernadett Kolozsvári. and Borbála Deák{-}Karancsi. and Renáta Czabány. and Bence Gyalai. and Tao Tan. and Zoltán Végváry. and Emőke Borzasi. and Zsófia Együd. and Renáta Kószó. and Viktor Paczona. and Emese Fodor. and Chad Bobb. and Cristina Cozzini. and Sandeep Kaushik. and Barbara Darázs. and Gerda M. Verduijn. and Rachel Pearson. and Ross Maxwell. and Hazel Mccallum. and Juan A. {Hernandez Tamames}. and Katalin Hideghéty. and Steven F. Petit. and Florian Wiesinger.},
title={Deep-Learning-based Segmentation of Organs-at-Risk in the Head for MR-assisted Radiation Therapy Planning},
booktitle={Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - BIOIMAGING},
year={2021},
pages={31-43},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0010235000002865},
isbn={978-989-758-490-9},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 14th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2021) - BIOIMAGING
TI - Deep-Learning-based Segmentation of Organs-at-Risk in the Head for MR-assisted Radiation Therapy Planning
SN - 978-989-758-490-9
IS - 2184-4305
AU - Ruskó, L.
AU - Capala, M.
AU - Czipczer, V.
AU - Kolozsvári, B.
AU - Deák-Karancsi, B.
AU - Czabány, R.
AU - Gyalai, B.
AU - Tan, T.
AU - Végváry, Z.
AU - Borzasi, E.
AU - Együd, Z.
AU - Kószó, R.
AU - Paczona, V.
AU - Fodor, E.
AU - Bobb, C.
AU - Cozzini, C.
AU - Kaushik, S.
AU - Darázs, B.
AU - Verduijn, G.
AU - Pearson, R.
AU - Maxwell, R.
AU - Mccallum, H.
AU - Hernandez Tamames, J.
AU - Hideghéty, K.
AU - Petit, S.
AU - Wiesinger, F.
PY - 2021
SP - 31
EP - 43
DO - 10.5220/0010235000002865
PB - SciTePress