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Authors: J. C. Calvo 1 ; J. Ortega 1 ; M. Anguita 1 ; J. Taheri 2 and A. Zomaya 2

Affiliations: 1 University of Granada, Spain ; 2 University of Sydney, Australia

ISBN: 978-989-8425-36-2

Keyword(s): Proteins, Torsion angles, Rotamer libraries.

Related Ontology Subjects/Areas/Topics: Algorithms and Software Tools ; Bioinformatics ; Biomedical Engineering ; Biostatistics and Stochastic Models ; Genomics and Proteomics ; Structure Prediction

Abstract: Protein structure prediction (PSP) is an open problem with many useful applications in disciplines such as Medicine, Biology and Biochemistry. As this problem presents a vast search space where the analysis of each protein structure requires a significant amount of computing time, it is necessary to propose efficient search procedures in this very large space of possible protein conformations. Thus, an important issue is to add vital information (such as rotamers) to the process to decrease its active search space –rotamers give statistical information about torsional angles and conformations. In this paper, we propose a new method to refine the torsional angles of a protein to remake/reconstruct its structures with more resemblance to its original structure. This approach could be used to improve the accuracy of the rotamer libraries and/or to extract information from the Protein Data Bank to facilitate solution of the PSP problem.

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Paper citation in several formats:
C. Calvo, J.; Ortega, J.; Anguita, M.; Taheri, J. and Zomaya, A. (2011). A METHOD TO IMPROVE THE ACCURACY OF PROTEIN TORSION ANGLES.In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011) ISBN 978-989-8425-36-2, pages 297-300. DOI: 10.5220/0003137502970300

@conference{bioinformatics11,
author={J. C. Calvo. and J. Ortega. and M. Anguita. and J. Taheri. and A. Zomaya.},
title={A METHOD TO IMPROVE THE ACCURACY OF PROTEIN TORSION ANGLES},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011)},
year={2011},
pages={297-300},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003137502970300},
isbn={978-989-8425-36-2},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011)
TI - A METHOD TO IMPROVE THE ACCURACY OF PROTEIN TORSION ANGLES
SN - 978-989-8425-36-2
AU - C. Calvo, J.
AU - Ortega, J.
AU - Anguita, M.
AU - Taheri, J.
AU - Zomaya, A.
PY - 2011
SP - 297
EP - 300
DO - 10.5220/0003137502970300

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