Authors:
Dwitiyanti
;
Ni Putu Ermi Hikmawanti
;
Kriana Efendi
;
Riana Puspa Dewi
and
Fernita Afriyani
Affiliation:
Universitas Muhammadiyah, Indonesia
Keyword(s):
extract, black cincau, black grass jelly, Mesona palustris Blume, anti-hyperlipidemic
Abstract:
In Indonesia, Mesona palustris Blume is known as the black cincau (black grass jelly). This plant has been used for various health condition. This study aims to determine the effectiveness of 70% ethanol extract from black cincau leaves as anti-hyperlipidemic on hyperlipidemic hamsters. The dried leaves were extracted
using 70% ethanol by maceration method. Syrian hamsters were divided into 7 groups of 4 hamsters), i.e. normal control group, positive control group (fenofibrate 1.235 mg/Kg body weight), positive control group (atorvastatin 2.4 mg/Kg body weight), negative control group, test groups with 3 dose variations (780, 1560,
and 3120 mg/Kg body weight each day). All groups except normal control group were induced with high-fat diet for 28 days. Parameters measured were decreased total blood cholesterol, LDL, triglycerides level, and increased blood HDL level. Treatment was performed for 14 days. The 70% ethanol extract of black cincau with a dose of 3120 mg/Kg body weight was
able to decrease blood total cholesterol level by 51.49%, blood LDL level by 49.92%, and blood triglyceride level by 45.70%. Extract with the dose is also able to increase blood HDL level by 29.30%. Fenofibrate was able to decrease blood triglyceride level by 50.62% and increase blood HDL level by 34.82%, whereas atorvastatin was able to decrease blood total cholesterol level by 54.34% and blood LDL level by 51.13%. It could be concluded that the 70% ethanol extract from
black cincau leaves is effective as an anti-hyperlipidemic agent in hyperlipidemic hamster equivalent to positive control group.
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