Authors:
Aulia Asman
;
Debby Sinthania
and
Linda Marni
Affiliation:
Nursing Diploma, Padang State University, Padang,, Indonesia
Keyword(s):
Epinephrine, FSH, LH.
Abstract:
Physical, chemical, and psychological stressors can affect the pulsatile frequency and amplitude of GnRH; this is important for FSH and LH secretion. Excessive increase in pulsation can reduce and stop FSH and LH secretion. This study aimed to prove the effect of epinephrine to FSH and LH levels. This study was an experimental laboratory with a post-test only control group design. This study used 24 female mice (Mus musculus) consisting of 6 groups, namely 1 control group and 5 treatment groups based on differences in the administration of epinephrine of 0.001 mg/ml, 0.002 mg/ml, 0.003 mg/ml, 0.004 mg/ml, and 0.005 mg/ml applied every day for 20 days starting at the beginning of the pro-estrus cycle. The results were analyzed using the One-Way ANOVA continued Multiple Comparisons Bonferroni test. The results showed that the dose difference in the administration of epinephrine gave a significant difference (p <0.05) on FSH and LH levels starting at 0.001 mg/ml and 0.002 mg/ml, 0.003 m
g/ml, 0.004 mg/ml,
0.005 mg/ml with control. It can be concluded that chemical stressors (epinephrine) can reduce FSH and LH levels. It is recommended that further research adds measurements on the levels of estrogen and progesterone and the levels of catecholamine.
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