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Authors: Tarunendu Mapder and Lipika Adhya

Affiliation: B. P. Poddar Institute of Management and Technology, India

ISBN: 978-989-8565-35-8

Keyword(s): Voltage Gated Ion Channel.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Computational Molecular Systems ; Structure Prediction

Abstract: Voltage-gated potassium ion-channels (Kv) play a key role in neurons. The ion-channel is a tetramer each having two domains: voltage senor-domain (VSD) and pore-domain (PD), with four (S1-S4) and two (S5-S6) α-helices respectively, which behave like macrodipoles. The VSD appears capable of adopting different orientations relative to the pore-domain of Kv channels in response to the variable (-70V to +30V) transmembrane-voltage controlling the passage-way of the K+ ions across the membrane. There is an immense progress in the study of voltage-gated channel; however the molecular mechanism underlying voltage sensing is still a matter of debate. Here, we have used a novel theoretical approach using electrostatic theory to identify the possible stable conformation of the voltage gated potassium ion-channel of Aeropyrum pernix (KvAP) at zero transmembrane-voltage by computing the minimum potential energy of the system embedded in hybrid dielectric environment. We have set up an algorithm t o generate data, which is presented graphically and then analyzed to study the configuration of the biological system of KvAP. It is observed that in ion-channel protein two adjacent α-helices behaving like a macrodipole conform to antiparallel arrangement and the involvement of the charged residues with the multidielectric environment gives the ion-channel protein different conformations. (More)

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Paper citation in several formats:
Mapder, T. and Adhya, L. (2013). Computational Study of the Electrostatic Coupling of Membrane-spanning α-Helices Controlled by Dielectric Media.In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013) ISBN 978-989-8565-35-8, pages 111-115. DOI: 10.5220/0004193601110115

@conference{bioinformatics13,
author={Tarunendu Mapder. and Lipika Adhya.},
title={Computational Study of the Electrostatic Coupling of Membrane-spanning α-Helices Controlled by Dielectric Media},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)},
year={2013},
pages={111-115},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004193601110115},
isbn={978-989-8565-35-8},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2013)
TI - Computational Study of the Electrostatic Coupling of Membrane-spanning α-Helices Controlled by Dielectric Media
SN - 978-989-8565-35-8
AU - Mapder, T.
AU - Adhya, L.
PY - 2013
SP - 111
EP - 115
DO - 10.5220/0004193601110115

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