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Author: Piotr Kaczmarek

Affiliation: Poznań Univeristy of Technology, Insitute of Control and Information Engeenering, Poland

Keyword(s): Electrical stimulation, Muscle model, Calcium release, Muscle fatigue.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Signal Processing ; Physiological Processes and Bio-Signal Modeling, Non-Linear Dynamics

Abstract: The aim of this study is to create a model which enables to explain the muscle fibre contraction due to various stimulation programs. The model accounts for Ca2+ release dynamics both as a result of an action potential and of a stimulus shape, duration and frequency. It has been assumed that the stimulus can directly activate the voltage-dependent receptors (dihydropiridine receptors) responsible for a Ca2+ release. The stimulation programs consisted of standard stimulation trains made of low and middle frequency square pulses. High frequency modulating harmonic signals have been tested to investigate the fibre fatigue effect. It has been observed that fatigue effect factors depend on the selected stimulation program. The results reveal that the fatigue effect could be minimized by changing the shape and frequency of the stimulation waveform. Such the model could be useful for a preliminary selection and optimization of the stimulus shape and the stimulation trains, thus reducing t he number of in vivo experiments. (More)

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Paper citation in several formats:
Kaczmarek, P. (2008). BIOPHYSICAL MODEL OF A MUSCLE FATIGUE PROCESS INVOLVING Ca2+ RELEASE DYNAMICS UPON THE HIGH FREQUENCY ELECTRICAL STIMULATION. In Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2008) - Volume 2: BIOSIGNALS; ISBN 978-989-8111-18-0; ISSN 2184-4305, SciTePress, pages 52-57. DOI: 10.5220/0001062300520057

@conference{biosignals08,
author={Piotr Kaczmarek.},
title={BIOPHYSICAL MODEL OF A MUSCLE FATIGUE PROCESS INVOLVING Ca2+ RELEASE DYNAMICS UPON THE HIGH FREQUENCY ELECTRICAL STIMULATION},
booktitle={Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2008) - Volume 2: BIOSIGNALS},
year={2008},
pages={52-57},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001062300520057},
isbn={978-989-8111-18-0},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the First International Conference on Bio-inspired Systems and Signal Processing (BIOSTEC 2008) - Volume 2: BIOSIGNALS
TI - BIOPHYSICAL MODEL OF A MUSCLE FATIGUE PROCESS INVOLVING Ca2+ RELEASE DYNAMICS UPON THE HIGH FREQUENCY ELECTRICAL STIMULATION
SN - 978-989-8111-18-0
IS - 2184-4305
AU - Kaczmarek, P.
PY - 2008
SP - 52
EP - 57
DO - 10.5220/0001062300520057
PB - SciTePress