Authors:
Roman Trobec
;
Matjaž Depolli
and
Viktor Avbelj
Affiliation:
Jožef Stefan Institute, Slovenia
Keyword(s):
ECG, Action potential, Repolarization, Myocardium, Computer simulation.
Related
Ontology
Subjects/Areas/Topics:
Biomedical Engineering
;
Health Information Systems
;
Physiological Modeling
Abstract:
An improved model of action potentials (AP) is proposed to increase the accuracy of simulated electrocardiograms (ECGs). ECG simulator is based on a spatial model of a left ventricle, composed of cubic cells. Three distinct APs, modeled with functions proposed by Wohlfard, have been assigned to the cells, forming epicardial, mid, and endocardial layers. Identification of exact parameter values for AP models has been done through optimization of the simulated ECGs. Results have shown that only through an introduction of a minor extension to the AP model, simulator is able to produce realistic ECGs. The same extension also proves essential for achieving a good fit between the measured and modeled APs.