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Authors: Rizky Arcinthya Rachmania ;  Hariyanti and Nurul Rochmah

Affiliation: Universitas Muhammadiyah (UHAMKA), Indonesia

ISBN: 978-989-758-349-0

Keyword(s): Citrus limon, COX-1, flavonoid derivatives, antiplatelet, docking

Abstract: Lemon (Citrus limon (Linn) Burm. f) is a plant that has efficacy as antiplatelet. Flavonoids in lemon potentially obstruct COX-1 (Cyclooxygenase-1) receptor which has an important role in increasing thromboxane A2 in the process of ischaemic stroke. This research aims at looking for flavonoids activity from citrus lemon which is expected to be the antiplatelet drug candidates. The method used in this research was the molecular docking method using Autodock Vina and Pymol software programs. The results showed that the value of ΔG binding affinity Aspirin as the standard ligand was -6,5 kcal/mol and lemon flavonoid derivatives that have the lowest ΔG binding affinity value was on Neohesperidin -15,4 kcal/mol and Rutin -15,3 kcal/mol. This research shows that Neohesperidin and Rutin in lemon can be used as drug candidate of antiplatelet in ischaemic stroke disease.

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Paper citation in several formats:
Rachmania, R.; Hariyanti, . and Rochmah, N. (2018). Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f) Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1 (COX-1) as Antiplatelet in Ischaemic Stroke Disease.In Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD, ISBN 978-989-758-349-0, pages 19-25. DOI: 10.5220/0008238700190025

@conference{mich-phd18,
author={Rizky Arcinthya Rachmania. and Hariyanti. and Nurul Rochmah.},
title={Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f) Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1 (COX-1) as Antiplatelet in Ischaemic Stroke Disease},
booktitle={Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,},
year={2018},
pages={19-25},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0008238700190025},
isbn={978-989-758-349-0},
}

TY - CONF

JO - Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development - Volume 1: MICH-PhD,
TI - Molecular Docking Study of Lemon (Citrus limon (Linn) Burm. f) Flavonoid Derivatives Compound in Receptor Cyclooxygenase-1 (COX-1) as Antiplatelet in Ischaemic Stroke Disease
SN - 978-989-758-349-0
AU - Rachmania, R.
AU - Hariyanti, .
AU - Rochmah, N.
PY - 2018
SP - 19
EP - 25
DO - 10.5220/0008238700190025

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