Authors:
Rudi Afrinanda
;
Yusa Ristiawati
;
Muhammad Shoufi Islami
and
Deasy Vanda Pertiwi
Affiliation:
Ahmad Dahlan University, Indonesia
Keyword(s):
Mangiferin, Mangifera indica, gel, wound healer, ulcus diabetic
Abstract:
Mango (Mangifera indica L.) leaves contain flavonoid which has anti-inflammatory and antioxidants effects that are beneficial on healing diabetic ulcers. The extract made in gel formulation because it was easy to dry, forming the washable film layer that provides a cool sensation on the skin. Gel components influence the stability of formula. To ensure gel quality, safety, and benefits, physical stability test was needed to fulfill the specifications and stability during storage. This study aimed to extract and identify the mangiferin as an active compound in mango leaves and to formulate Mangifera indica leaves extract gel as a wound healer. Extraction of Mangifera indica leaves used soxhlet method with ethanol 70% and determined using TLC-densitometry method. The optimum formula of the gel was determined by variations of CMC-Na concentration as gel base, and the compliance of the gel characteristics. The analysis of characteristics included spreadability test, homogeneity test, adh
esivity test, and pH test. The result of extraction was determined by TLC-Densitometry as 330,52 mg/gram of viscous extract. The formula with 5% CMC-Na gel base complied with the required characteristics and was the optimum formula, which stability analysis did not show any changes in pH, colour, consistency, adhesivity and spreadability during storage.
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