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Authors: Ka-Lok Ng and Chia-Wei Weng

Affiliation: Asia University, Taiwan

ISBN: 978-989-674-019-1

Keyword(s): MicroRNA, Oncogene, Tumor suppressor gene, Gene expression profile, Correlation coefficient.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Databases and Data Management ; Web Services in Bioinformatics

Abstract: We investigate the possibility that microRNA can act as an oncogene or tumor suppressor gene. Experimentally verified microRNA target genes information (TarBase) are integrated with microRNA and mRNA expression data (NCI-60) to study this hypothesis, in which the Pearson correlation and Spearman rank coefficients are used to quantify these relations for nine cancer types. Correlation coefficients with negative values are used to filter out microRNA targets. Biological annotations of the targets are supplied by using the TAG, GO and KEGG records. The above information are utilized to provide a platform in identifying potential cancer related microRNAs. A web based interface is set up for information query and data display.

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Paper citation in several formats:
Ng K.; Weng C. and (2010). IN SILICO STUDY OF EXPRESSION PROFILES CORRELATION BETWEEN MICRORNAS AND CANCEROUS GENES.In Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010) ISBN 978-989-674-019-1, pages 141-146. DOI: 10.5220/0002728701410146

@conference{bioinformatics10,
author={Ka{-}Lok Ng and Chia{-}Wei Weng},
title={IN SILICO STUDY OF EXPRESSION PROFILES CORRELATION BETWEEN MICRORNAS AND CANCEROUS GENES},
booktitle={Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010)},
year={2010},
pages={141-146},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002728701410146},
isbn={978-989-674-019-1},
}

TY - CONF

JO - Proceedings of the First International Conference on Bioinformatics - Volume 1: BIOINFORMATICS, (BIOSTEC 2010)
TI - IN SILICO STUDY OF EXPRESSION PROFILES CORRELATION BETWEEN MICRORNAS AND CANCEROUS GENES
SN - 978-989-674-019-1
AU - Ng, K.
AU - Weng, C.
PY - 2010
SP - 141
EP - 146
DO - 10.5220/0002728701410146

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