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Authors: Giuseppe Pontrelli 1 ; Andrea Di Mascio 1 and Filippo de Monte 2

Affiliations: 1 CNR, Italy ; 2 University of L’Aquila, Italy

ISBN: 978-989-8565-69-3

ISSN: 2184-2841

Keyword(s): Diffusion-reaction Equation, Transdermal Drug Delivery, Percutaneous Absorption, Local Mass Nonequilibrium.

Abstract: One of the most promising frontiers of bioengineering is the controlled release of a therapeutic drug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a multiphase mathematical model describing the dynamics of a substance between two porous coupled media of different properties and extents is presented. A system of partial differential equation describes the diffusion and the reversible binding and unbinding processes in both layers. Additional flux continuity at the interface and clearance conditions into systemic circulation are imposed. A Sturm-Liouville problem is solved and an analytical solution is given in the form of an infinite series expansion. The model points out the role of the diffusion and reaction parameters, which control the complex transfer mechanism and the drug kinetics across the two layers. Drug mass are given and their dependence on the physical parameters are discussed.

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Paper citation in several formats:
Pontrelli, G.; Di Mascio, A. and de Monte, F. (2013). Modelling Transdermal Drug Delivery through a Two-layered System.In Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: BIOMED, (SIMULTECH 2013) ISBN 978-989-8565-69-3, ISSN 2184-2841, pages 645-651. DOI: 10.5220/0004619706450651

@conference{biomed13,
author={Giuseppe Pontrelli. and Andrea Di Mascio. and Filippo de Monte.},
title={Modelling Transdermal Drug Delivery through a Two-layered System},
booktitle={Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: BIOMED, (SIMULTECH 2013)},
year={2013},
pages={645-651},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004619706450651},
isbn={978-989-8565-69-3},
}

TY - CONF

JO - Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - Volume 1: BIOMED, (SIMULTECH 2013)
TI - Modelling Transdermal Drug Delivery through a Two-layered System
SN - 978-989-8565-69-3
AU - Pontrelli, G.
AU - Di Mascio, A.
AU - de Monte, F.
PY - 2013
SP - 645
EP - 651
DO - 10.5220/0004619706450651

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