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Authors: You-Lin Wu 1 ; Po-Yen Hsu 1 ; Chung-Ping Hsu 2 and Wen- Cheng Liu 1

Affiliations: 1 National Chi Nan University, Taiwan ; 2 Taichung Veterans General Hospital, Taiwan

ISBN: 978-989-674-017-7

Keyword(s): DNA bases detection, Polysilicon wire sensor, Label-free.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Instruments and Devices ; Biomedical Sensors

Abstract: In this paper we report the electrical measurement of sequence-specific and label-free deoxyribonucleic acid (DNA) by using poly-silicon (poly-Si) wire. Four single-strained (ss) DNA bases, adenine (A), thymine (T), cytosine (C) and guanines (G), as well as double-stranded (ds) DNA sequences, ds(A-T) and ds(C-G), with different lengths and concentrations were dropped onto the poly-Si wire surface, and currents flowing through the poly-Si wire channel were determined. It is found that the amount change of the channel current I for ssDNAs with fixed length and fixed concentration is that T > C > G > A. For dsDNA sequence, we observe that ds(A-T) has higher I than does ds(C-G). We also prove that single base change in ssDNA is feasible by using the poly-Si wire sensor.

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Paper citation in several formats:
Wu Y.; Hsu P.; Hsu C.; Liu W. and (2010). ELECTRICAL CHARACTERIZATION OF SEQUENCE-SPECIFIC LABEL-FREE DNA BY USING POLYSILICON WIRE.In Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010) ISBN 978-989-674-017-7, pages 170-173. DOI: 10.5220/0002712601700173

@conference{biodevices10,
author={You{-}Lin Wu and Po{-}Yen Hsu and Chung{-}Ping Hsu and Wen{-} Cheng Liu},
title={ELECTRICAL CHARACTERIZATION OF SEQUENCE-SPECIFIC LABEL-FREE DNA BY USING POLYSILICON WIRE},
booktitle={Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010)},
year={2010},
pages={170-173},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0002712601700173},
isbn={978-989-674-017-7},
}

TY - CONF

JO - Proceedings of the Third International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, (BIOSTEC 2010)
TI - ELECTRICAL CHARACTERIZATION OF SEQUENCE-SPECIFIC LABEL-FREE DNA BY USING POLYSILICON WIRE
SN - 978-989-674-017-7
AU - Wu, Y.
AU - Hsu, P.
AU - Hsu, C.
AU - Liu, W.
PY - 2010
SP - 170
EP - 173
DO - 10.5220/0002712601700173

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