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Modeling of Cardiac Component of Subarachnoid Space Changes in Apnoea Resulting as a Function of Blood Pressure and Blood Flow Parameters - Two Mechanizm of Regulation

Topics: Biostatistics and Stochastic Models; Databases and Data Management; Model Design and Evaluation; Pharmaceutical Applications; Simulation and Modeling; Structural Bioinformatics; Systems Biology

Authors: Kamila Mazur 1 ; Renata Kalicka 1 ; Andrzej F. Frydrychowski 2 and Pawel J. Winklewski 2

Affiliations: 1 Faculty of Electronics, Telecommunications and Informatics and Gdańsk University of Technology, Poland ; 2 Medical University of Gdansk, Poland

ISBN: 978-989-758-214-1

ISSN: 2184-4305

Keyword(s): Subarachnoid Space Width, Pial Artery, Brain Haemodynamics, Apnea, NIR-T/BSS.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Biostatistics and Stochastic Models ; Databases and Data Management ; Model Design and Evaluation ; Pharmaceutical Applications ; Structural Bioinformatics ; Systems Biology

Abstract: Experiments were performed in a group of 19 healthy, non-smoking volunteers. The experiment consisted of three apnoeas, sequentially: 30 s apnoea, 60 s apnoea and maximal, that could be done, apnoea. The breath-hold was separated for 5 minutes rest. The following parameters were measured and obtained for further analysis: blood parameters, artery diameter of the internal carotid artery, end-tidal CO2 in expired air, the cardiac (from 0.5 to 5.0 Hz) and slow (< 0.5 Hz) components of subarachnoid space width signal. As a result of the experiment, we observed two different reactions, using the same experimental procedure. It seemed to indicate two different operating modes and two separate models. As a consequence, there are two subsets of slow subarachnoid space width responses to breath-hold in humans. A positive subarachnoid space width changes (slow) component depends on changes in heart rate, pulsatility index and cerebral blood flow velocity. A negative subarachnoid space width cha nges component is driven by heart rate changes and pulsatility index changes. The different heart-generated arterial pulsation response to experimental breath-hold provides new insights into our understanding of the complex mechanisms governing the adaptation to apnoea in humans. We propose a mathematical methodology that can be used in further clinical research. (More)

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Paper citation in several formats:
Mazur, K.; Kalicka, R.; Frydrychowski, A. and Winklewski, P. (2017). Modeling of Cardiac Component of Subarachnoid Space Changes in Apnoea Resulting as a Function of Blood Pressure and Blood Flow Parameters - Two Mechanizm of Regulation. In Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017) ISBN 978-989-758-214-1 ISSN 2184-4305, pages 140-147. DOI: 10.5220/0006139901400147

@conference{bioinformatics17,
author={Kamila Mazur. and Renata Kalicka. and Andrzej F. Frydrychowski. and Pawel J. Winklewski.},
title={Modeling of Cardiac Component of Subarachnoid Space Changes in Apnoea Resulting as a Function of Blood Pressure and Blood Flow Parameters - Two Mechanizm of Regulation},
booktitle={Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017)},
year={2017},
pages={140-147},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006139901400147},
isbn={978-989-758-214-1},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, (BIOSTEC 2017)
TI - Modeling of Cardiac Component of Subarachnoid Space Changes in Apnoea Resulting as a Function of Blood Pressure and Blood Flow Parameters - Two Mechanizm of Regulation
SN - 978-989-758-214-1
IS - 2184-4305
AU - Mazur, K.
AU - Kalicka, R.
AU - Frydrychowski, A.
AU - Winklewski, P.
PY - 2017
SP - 140
EP - 147
DO - 10.5220/0006139901400147

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