Authors:
Saikhu Akhmad Husen
1
;
Salamun
2
;
Arif Nur Muhammad Ansori
3
;
Raden Joko Kuncoroningrat Susilo
2
;
Suhailah Hayaza
2
and
Dwi Winarni
1
Affiliations:
1
Department of Biology, Faculty of Science and Technology Universitas Airlangga, Kampus C Universitas Airlangga, Surabaya, Indonesia, Animal Histology Laboratory, Faculty of Science and Technology Universitas Airlangga, Kampus C Universitas Airlangga, Surabaya and Indonesia, Indonesia
;
2
Department of Biology, Faculty of Science and Technology Universitas Airlangga, Kampus C Universitas Airlangga, Surabaya and Indonesia, Indonesia
;
3
Faculty of Veterinary Medicine Universitas Airlangga, Kampus C Universitas Airlangga, Surabaya and Indonesia, Indonesia
Keyword(s):
Alpha-mangostin, antidiabetic, antilipidemic, diabetic mice, streptozotocin
Abstract:
The increasing prevalence of Diabetes Mellitus (DM) worldwide is an issue of major socio-economic concern. DM is a complex and a multifarious group of disorders that disturbs the metabolism of carbohydrates, fat, and protein. Medicinal plants play an important role in the management of DM, especially in developing countries. The aim of this study is to investigate the antidiabetic and antilipidemic effects of alpha-mangostin in STZ-induced diabetic mice. We conducted the study using the male BALB/C mice. The mice were divided into two groups: the normal control (KN) and the STZ-induced diabetic mice. Streptozotocin (STZ) induction was performed using multiple low-doses of 30 mg/kg bw injected for five consecutive days. The diabetic mice were grouped again into three subgroups: diabetic control (KD), metformin HCL treated diabetic mice (KM), and diabetic mice which were treated using alpha-mangostin at 2 mg/kg bw (P1), 4 mg/kg bw (P2), and 8 mg/kg bw (P3). Before and after STZ injecti
on, the blood glucose and the cholesterol levels were observed. The blood glucose and the cholesterol levels were also measured on the 1st, 7th, and 14th day of alpha-mangostin treatments. Treatment was given for 14 days. At the 15th day, the pancreases were collected and then processed into histological slides. The results of this experimental study indicated that alpha-mangostin has hypoglycemic and hypolipidemic activities which can ameliorate the damaged islets of Langerhans in STZ-induced diabetic mice. Therefore, we concluded that alpha-mangostin is a promising antidiabetic and antilipidemic agent due to its antioxidant activity.
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