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Authors: Jaroslav Albert and Marianne Rooman

Affiliation: Université Libre de Bruxelles, Belgium

ISBN: 978-989-8425-36-2

Keyword(s): Bistable genetic switches, Delays, Modeling gene expression, Moise, Robustness.

Related Ontology Subjects/Areas/Topics: Agents ; Artificial Intelligence ; Bioinformatics ; Biomedical Engineering ; Enterprise Information Systems ; Information Systems Analysis and Specification ; Methodologies and Technologies ; Operational Research ; Simulation ; Systems Biology

Abstract: Among other functions, bistable genetic switches serve as decision-makers, accepting or rejecting noisy input signals. In some instances, e. g. during developmental stages, it is imperative that, once an input signal is accepted, the gene’s expression remains virtually unchanged for a certain period of time before evolving to its other stationary state. In this paper, we aim to tackle the question of what causes this delay to occur. We look at a particular model of a bistable switch and study the conditions which lead to delayed state transitions. Given that every biological system is subject to noise, it is imperative that any model capable of explaining and predicting these delays is robust against random parameter perturbations. Therefore, in order to test the robustness of the model, we subject the system to random noise and show that for particular combinations of parameter values, its effects on the delays are negligible. It is demonstrated that the ratio of protein to mRNA degr adation rates plays a critical role in the system’s confidence to generate accurate delays. (More)

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Paper citation in several formats:
Albert, J. and Rooman, M. (2011). MODELING DELAYS IN STATE TRANSITION OF A BISTABLE GENETIC SWITCH UNDER THE INFLUENCE OF EXTRINSIC NOISE.In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011) ISBN 978-989-8425-36-2, pages 278-282. DOI: 10.5220/0003133402780282

@conference{bioinformatics11,
author={Jaroslav Albert. and Marianne Rooman.},
title={MODELING DELAYS IN STATE TRANSITION OF A BISTABLE GENETIC SWITCH UNDER THE INFLUENCE OF EXTRINSIC NOISE},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011)},
year={2011},
pages={278-282},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003133402780282},
isbn={978-989-8425-36-2},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms - Volume 1: BIOINFORMATICS, (BIOSTEC 2011)
TI - MODELING DELAYS IN STATE TRANSITION OF A BISTABLE GENETIC SWITCH UNDER THE INFLUENCE OF EXTRINSIC NOISE
SN - 978-989-8425-36-2
AU - Albert, J.
AU - Rooman, M.
PY - 2011
SP - 278
EP - 282
DO - 10.5220/0003133402780282

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