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Authors: Khairunnisa Abd Rauf 1 ; Erry Gumilar Dachlan 2 and Ariyanto Harsono 3

Affiliations: 1 Master Student of Immunology, Postgraduate School Universitas Airlangga, Surabaya and Indonesia, Indonesia ; 2 Department of Obstetrics and Gynaecology, RS DR Soetomo, Surabaya and Indonesia, Indonesia ; 3 Department of Pediatrics, RS Dr Soetomo, Surabaya and Indonesia, Indonesia

Keyword(s): decidual, immunohistochemistry, KIR2DL1, placenta

Abstract: A successful spiral artery remodelling ensures adequate uteroplacental perfusion and sufficient nutrient supply to fetus. HLA-C interaction with maternal KIR determines the outcome of spiral artery remodelling. Strong KIR2DL1 inhibitory lowers cytokine expression and angiogenic factors that affect uteroplacental perfusion and nutrient supply. We analysed the decidual expression of KIR2DL1 in early-onset preeclampsia (EO-PE) and late-onset preeclampsia (LO-PE) groups. We found a significant difference between KIR2DL1 expression and EO-PE and LO-PE groups (p <0.001), with a strong negative correlation between decidual expression of KIR2DL1 and EO-PE (p <0.001, r=-0.723), birth weight (p <0.001, r=-0,.70) and placental weight (p <0.001, r=-0.770).

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Paper citation in several formats:
Rauf, K.; Dachlan, E. and Harsono, A. (2019). Decidual Killer Immunoglobulin-Like Receptor (KIR)2DL1 Expression and the Onset of Preeclampsia, Birth Weight and Placental Weight in Early and Late Onset Preeclampsia. In Proceedings of the 2nd International Conference Postgraduate School - ICPS; ISBN 978-989-758-348-3, SciTePress, pages 321-324. DOI: 10.5220/0007542103210324

@conference{icps19,
author={Khairunnisa Abd Rauf. and Erry Gumilar Dachlan. and Ariyanto Harsono.},
title={Decidual Killer Immunoglobulin-Like Receptor (KIR)2DL1 Expression and the Onset of Preeclampsia, Birth Weight and Placental Weight in Early and Late Onset Preeclampsia},
booktitle={Proceedings of the 2nd International Conference Postgraduate School - ICPS},
year={2019},
pages={321-324},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0007542103210324},
isbn={978-989-758-348-3},
}

TY - CONF

JO - Proceedings of the 2nd International Conference Postgraduate School - ICPS
TI - Decidual Killer Immunoglobulin-Like Receptor (KIR)2DL1 Expression and the Onset of Preeclampsia, Birth Weight and Placental Weight in Early and Late Onset Preeclampsia
SN - 978-989-758-348-3
AU - Rauf, K.
AU - Dachlan, E.
AU - Harsono, A.
PY - 2019
SP - 321
EP - 324
DO - 10.5220/0007542103210324
PB - SciTePress