Authors:
Kristiadi Priambodo
1
;
Jefman Efendi Marzuki HY
2
;
Risma Ikawaty
2
;
Baharuddin
2
and
Salsa Bella Destri Syafika
1
Affiliations:
1
Bachelor of Medicine Program, Medical Faculty, University of Surabaya, Surabaya, 60293, Indonesia, Indonesia
;
2
Faculty of Medicine, University of Surabaya, Surabaya, 60293, Indonesia
Keyword(s):
Mapping of science, CYP2 gene, precision medicine, bibliometrik.
Abstract:
This study elucidates the role of the CYP2 gene family in the pharmacokinetics and pharmacodynamics of drugs. The variability in these genes significantly influences drug efficacy and individual response. With the increasing volume of scientific publications, a comprehensive understanding of the current research on the CYP2 gene family is crucial. Numerous studies have examined these genetic variations, yet a thorough assessment of this research landscape and the identification of unexplored areas are still needed. Through bibliometric analysis and global mapping, this study enables a more systematic interpretation of publication data, offering new insights. The aim is to perform scientific mapping and interpretation of the CYP2 gene family research corpus. Utilizing literature review methods and bibliometric analysis based on PRISMA guidelines, a search in the Scopus database with the keyword cyp2* yielded 11,867 articles. After cleaning and preparation, 9,439 articles remained for
analysis. The results indicate a significant increase in CYP2 gene research, particularly between 2012-2023. Mapping reveals five main clusters, with CYP2E1 and CYP2D6 as the largest. CYP2C9 stands out for its polarization with three other clusters, indicating strong research collaboration. Identified strategic areas include opioids, atrial fibrillation, PCI, DNA methylation, hepatocellular carcinoma, and bile acid. Key genes in polymorphism studies include CYP2C19 and CYP2C8, while CYP2D6 is crucial in drug monitoring. This science mapping provides essential insights for research development in precision medicine.
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