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Authors: Yu Yong Choi 1 and Kun Ho Lee 2

Affiliations: 1 Hanyang University, Korea, Republic of ; 2 Chosun University, Korea, Republic of

Keyword(s): heritability, structural equation modeling, Falconer’s formula, neuroimaging, correction of multiple comparisons.

Abstract: Heritability is the proportion of total phenotypic variance due to genetic influence. To estimate heritability, Falconer’s method and structural equation modeling (SEM) are used. However, compared to Falconer’s formula, SEM is hardly applicable for neuroimaging analysis because the SEM tools such as Mx cannot calculate numerous data simultaneously nor sequentially. We developed a code for multiple calculations using Mx to estimate the heritability of gray matter thickness at 81,924 surface points across the cerebral cortex. Although FF and SEM provided similar results, SEM was inclined to yield lower heritability estimates and more conservative significance than Falconer’s method. In considering the results, we propose that the correction for multiple comparisons should be carefully performed for the results from SEM.

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Paper citation in several formats:
Choi, Y. and Lee, K. (2011). Heritability Estimation Methods of Multiple Brain Measures: A Preliminary MRI Study in Twins . In Proceedings of the 2nd International Workshop on Medical Image Analysis and Description for Diagnosis Systems - MIAD, (BIOSTEC 2011) ISBN 978-989-8425-38-6, pages 82-87. DOI: 10.5220/0003305100820087

@conference{miad11,
author={Yu Yong Choi. and Kun Ho Lee.},
title={Heritability Estimation Methods of Multiple Brain Measures: A Preliminary MRI Study in Twins },
booktitle={Proceedings of the 2nd International Workshop on Medical Image Analysis and Description for Diagnosis Systems - MIAD, (BIOSTEC 2011)},
year={2011},
pages={82-87},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003305100820087},
isbn={978-989-8425-38-6},
}

TY - CONF

JO - Proceedings of the 2nd International Workshop on Medical Image Analysis and Description for Diagnosis Systems - MIAD, (BIOSTEC 2011)
TI - Heritability Estimation Methods of Multiple Brain Measures: A Preliminary MRI Study in Twins
SN - 978-989-8425-38-6
AU - Choi, Y.
AU - Lee, K.
PY - 2011
SP - 82
EP - 87
DO - 10.5220/0003305100820087