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Authors: Maura Cárdenas-García 1 and Pedro Pablo González Pérez 2

Affiliations: 1 Benemérita Universidad Autónoma de Puebla, Mexico ; 2 Universidad Autónoma Metropolitana, Mexico

ISBN: 978-989-758-280-6

ISSN: 2184-4305

Keyword(s): In Silico Approach, Modelling and Simulation, Intercellular Interaction, Cancer Cells, Signalling Pathways.

Related Ontology Subjects/Areas/Topics: Algorithms and Software Tools ; Bioinformatics ; Biomedical Engineering

Abstract: Intercellular interaction allows cancer cells to preserve their malignance and through cell junctions to induce malignance in neighbouring cells and receive nutrients from them. The Wnt (wingless-related integration site) signalling pathway plays an important role in the formation of intercellular communications. In this work, we explore the complex interactions patterns of intercellular communication in cancer cells using an in silico modelling and simulation methodology developed by us. The proposed cellular signalling model, characterized by a multicompartmental nature, provides symbolic abstractions and accurate algorithms to model both intracellular and intercellular behaviours. In particular, in this work, we propose an in silico model and simulation of the formation of different communication channels, involving the Wnt signalling pathway. The final purpose of this study is to propose target molecules leading to break the communication between a cancer cell and surrounding norm al cells. In this way, it is not necessary to carry out long series of different in vitro experiments, but only a few, because the focus should be only on the key molecules, which saves time and money. We observed, using in silico experiments, how the inhibition of Wnt signalling pathway prevents that the cells surrounding a cancerous cell are transformed. (More)

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Paper citation in several formats:
Cárdenas-García, M. and González Pérez, P. (2018). An in Silico Approach for Understanding the Complex Intercellular Interaction Patterns in Cancer Cells.In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS, ISBN 978-989-758-280-6, ISSN 2184-4305, pages 188-195. DOI: 10.5220/0006722601880195

@conference{bioinformatics18,
author={Maura Cárdenas{-}García. and Pedro Pablo González Pérez.},
title={An in Silico Approach for Understanding the Complex Intercellular Interaction Patterns in Cancer Cells},
booktitle={Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS,},
year={2018},
pages={188-195},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0006722601880195},
isbn={978-989-758-280-6},
}

TY - CONF

JO - Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3 BIOINFORMATICS: BIOINFORMATICS,
TI - An in Silico Approach for Understanding the Complex Intercellular Interaction Patterns in Cancer Cells
SN - 978-989-758-280-6
AU - Cárdenas-García, M.
AU - González Pérez, P.
PY - 2018
SP - 188
EP - 195
DO - 10.5220/0006722601880195

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