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Authors: Christopher E. Gillies 1 ; Mohammad-Reza Siadat 1 ; Nilesh V. Patel 1 and George Wilson 2

Affiliations: 1 Oakland University, United States ; 2 William Beaumont Hospitals, United States

ISBN: 978-989-8425-79-9

Keyword(s): Gene ontology, Gene ontology annotation, Gene expression profile classification, Feature selection, Dimensionality reduction and simulation.

Related Ontology Subjects/Areas/Topics: Artificial Intelligence ; BioInformatics & Pattern Discovery ; Knowledge Discovery and Information Retrieval ; Knowledge-Based Systems ; Mining High-Dimensional Data ; Symbolic Systems

Abstract: Increasing interest among researchers is evidenced for techniques that incorporate prior biological knowledge into gene expression profile classifiers. Specifically, researchers are interested in learning the impact on classification when prior knowledge is incorporated into a classifier rather than just using the statistical properties of the dataset. In this paper, we investigate this impact through simulation. Our simulation relies on an algorithm that generates gene expression data from Gene Ontology. Experiments comparing two classifiers, one trained using only statistical properties and one trained with a combination of statistical properties and Gene Ontology knowledge, are discussed . Experimental results suggest that incorporating Gene Ontology information improves classifier performance. In addition, we discuss the relationship of distance between means of the distributions of the classes and the training sample size on classification accuracy.

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Paper citation in several formats:
E. Gillies, C.; Siadat, M.; V. Patel, N. and Wilson, G. (2011). GENE ONTOLOGY BASED SIMULATION FOR FEATURE SELECTION.In Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2011) ISBN 978-989-8425-79-9, pages 286-294. DOI: 10.5220/0003665502940302

@conference{kdir11,
author={Christopher E. Gillies. and Mohammad{-}Reza Siadat. and Nilesh V. Patel. and George Wilson.},
title={GENE ONTOLOGY BASED SIMULATION FOR FEATURE SELECTION},
booktitle={Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2011)},
year={2011},
pages={286-294},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003665502940302},
isbn={978-989-8425-79-9},
}

TY - CONF

JO - Proceedings of the International Conference on Knowledge Discovery and Information Retrieval - Volume 1: KDIR, (IC3K 2011)
TI - GENE ONTOLOGY BASED SIMULATION FOR FEATURE SELECTION
SN - 978-989-8425-79-9
AU - E. Gillies, C.
AU - Siadat, M.
AU - V. Patel, N.
AU - Wilson, G.
PY - 2011
SP - 286
EP - 294
DO - 10.5220/0003665502940302

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