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Authors: Petr Simecek ; Maria Dzur-Gejdosova ; Irena Chvatalova and Jiri Forejt

Affiliation: Institute of Molecular Genetics of the ASCR and Center for Applied Genomics, Czech Republic

Keyword(s): Litter effect, Mixed-effect models, Phenome databases, Mouse genetics.

Related Ontology Subjects/Areas/Topics: Bioinformatics ; Biomedical Engineering ; Biostatistics and Stochastic Models ; Data Mining and Machine Learning

Abstract: The laboratory mouse is the most common mammalian model organism for research of the human body functions and disorders. For experimental purposes mice selected from inbred strains, developed by many generations of brother-sister crosses, are usually used. Individual mice of a given inbred strain are therefore considered genetically identical. However, our preliminary observations suggest that for a number of phenotypic traits mice originating from the same litter are significantly more similar than mice coming from different litters of the same inbred strain. We estimated the size of this litter effect for a number of traits in several phenotypic studies. By means of simulation we showed that ignoring the litter effect may result in several fold higher false positive rate and severe underestimation of minimal sample size.

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Paper citation in several formats:
Simecek, P.; Dzur-Gejdosova, M.; Chvatalova, I. and Forejt, J. (2011). LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES. In Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2011) - BIOINFORMATICS; ISBN 978-989-8425-36-2; ISSN 2184-4305, SciTePress, pages 238-243. DOI: 10.5220/0003173602380243

@conference{bioinformatics11,
author={Petr Simecek. and Maria Dzur{-}Gejdosova. and Irena Chvatalova. and Jiri Forejt.},
title={LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES},
booktitle={Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2011) - BIOINFORMATICS},
year={2011},
pages={238-243},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0003173602380243},
isbn={978-989-8425-36-2},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the International Conference on Bioinformatics Models, Methods and Algorithms (BIOSTEC 2011) - BIOINFORMATICS
TI - LITTER EFFECT IN MOUSE PHENOTYPIC STUDIES
SN - 978-989-8425-36-2
IS - 2184-4305
AU - Simecek, P.
AU - Dzur-Gejdosova, M.
AU - Chvatalova, I.
AU - Forejt, J.
PY - 2011
SP - 238
EP - 243
DO - 10.5220/0003173602380243
PB - SciTePress

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