Authors:
Thomas Hinze
;
Mathias Schumann
and
Stefan Schuster
Affiliation:
Friedrich Schiller University Jena, Germany
Keyword(s):
Chronobiology, Coupled repressilators, Reaction-diffusion kinetics, Internal/external clock synchronisation, Control system, Phase-locked loop.
Related
Ontology
Subjects/Areas/Topics:
Biomedical Engineering
;
Biomedical Signal Processing
;
Informatics in Control, Automation and Robotics
;
Physiological Processes and Bio-Signal Modeling, Non-Linear Dynamics
;
Real-Time Systems
;
Signal Processing, Sensors, Systems Modeling and Control
;
Time and Frequency Response
;
Time-Frequency Analysis
Abstract:
Exploration of chronobiological systems emerges as a growing research field within bioinformatics focusing on various applications in medicine, agriculture, and material sciences. From a systems biological perspective, the question arises whether biological control systems for regulation of oscillative signals and their technical counterparts utilise similar mechanisms. If so, modelling approaches and parameterisation adopted from building blocks can help to identify general components for clock synchronisation. Phase-locked loops could be an interesting candidate in this context. Both, biology and engineering, can benefit from a unified view. In a first experimental study, we analyse a model of coupled repressilators. We demonstrate its ability to synchronise clock signals in a monofrequential manner. Several oscillators initially deviate in phase difference and frequency with respect to explicit reaction and diffusion rates. Accordingly, the duration of the synchronisation process
depends on dedicated reaction and diffusion parameters whose settings still lack to be sufficiently captured by comprehensive tools like the Kuramoto approach.
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