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Authors: T. Clees ; N. Hornung ; I. Nikitin ; L. Nikitina and D. Steffes-lai

Affiliation: Fraunhofer Institute for Algorithms and Scientific Computing, Germany

Keyword(s): Stochastic Modeling and Simulation, Multi-objective Optimization, Healthcare.

Related Ontology Subjects/Areas/Topics: Application Domains ; Applications and Uses ; Biomedical Engineering ; Computer Simulation Techniques ; Formal Methods ; Health Information Systems ; Healthcare ; Optimization Issues ; Sensor Networks ; Simulation and Modeling ; Simulation Tools and Platforms ; Stochastic Modeling and Simulation

Abstract: We present new results in stochastic multi-objective optimization applied to focused ultrasonic therapy planning. This type of non-invasive therapy uses focused ultrasound for the destruction of tumor cells and magnetic resonance tomography for identification of tumor volume and healthy organs. During the therapy planning the treatment parameters, such as frequency and intensity of ultrasound, are adjusted to achieve maximal tumor destruction and minimal influence to the healthy organs. For this purpose multi-objective optimization is used. RBF metamodeling is employed for continuous representation of discretely sampled results of numerical simulation and for evaluation of inherent uncertainties. We apply two algorithms for multi-objective optimization capable of non-convex Pareto front detection in the considered problem. Cross-validation procedure and sensitivity analysis are used for estimation of uncertainties. A realistic application case demonstrates the efficiency of the appr oach. (More)

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Paper citation in several formats:
Clees, T.; Hornung, N.; Nikitin, I.; Nikitina, L. and Steffes-lai, D. (2013). Multi-objective Optimization and Stochastic Analysis in Focused Ultrasonic Therapy Simulation. In Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - SIMULTECH; ISBN 978-989-8565-69-3; ISSN 2184-2841, SciTePress, pages 43-48. DOI: 10.5220/0004421900430048

@conference{simultech13,
author={T. Clees. and N. Hornung. and I. Nikitin. and L. Nikitina. and D. Steffes{-}lai.},
title={Multi-objective Optimization and Stochastic Analysis in Focused Ultrasonic Therapy Simulation},
booktitle={Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - SIMULTECH},
year={2013},
pages={43-48},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0004421900430048},
isbn={978-989-8565-69-3},
issn={2184-2841},
}

TY - CONF

JO - Proceedings of the 3rd International Conference on Simulation and Modeling Methodologies, Technologies and Applications - SIMULTECH
TI - Multi-objective Optimization and Stochastic Analysis in Focused Ultrasonic Therapy Simulation
SN - 978-989-8565-69-3
IS - 2184-2841
AU - Clees, T.
AU - Hornung, N.
AU - Nikitin, I.
AU - Nikitina, L.
AU - Steffes-lai, D.
PY - 2013
SP - 43
EP - 48
DO - 10.5220/0004421900430048
PB - SciTePress

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