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Authors: Noah A. Wilson ; Robin Abu-Shumays ; Elizabeth Koch ; Seico Benner and William B. Dunbar

Affiliation: Dynamics and Control Laboratory, Computer Engineering and Biomolecular Engineering, University of California, United States

Keyword(s): Nanopore, single molecule control, finite state machine.

Related Ontology Subjects/Areas/Topics: Biomedical Engineering ; Biomedical Instruments and Devices ; Biomedical Sensors ; Nanotechnologies

Abstract: This paper demonstrates feedback voltage control of individual DNA hairpin molecules captured in a nanopore. A finite state machine is used to program voltage control logic, executed on a field-programmable gate array, for rapid detection and regulation of hundreds of DNA hairpins, one at a time. Prompt voltage reduction is used for extension of the dwell time of DNA hairpins in the nanopore. Then, voltage reversal after a preset dwell time is used for automated expulsion of molecules prior to hairpin unzipping. The demonstrated control authority of single molecular complexes captured in the nanopore device is an integral part of our ongoing research for direct monitoring and control of enzyme-bound biopolymers.

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Paper citation in several formats:
A. Wilson, N.; Abu-Shumays, R.; Koch, E.; Benner, S. and B. Dunbar, W. (2008). RAPID FINITE STATE MACHINE CONTROL OF INDIVIDUAL DNA MOLECULES IN A NANOPORE. In Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 2: BIODEVICES; ISBN 978-989-8111- 17-3; ISSN 2184-4305, SciTePress, pages 93-98. DOI: 10.5220/0001053000930098

@conference{biodevices08,
author={Noah {A. Wilson}. and Robin Abu{-}Shumays. and Elizabeth Koch. and Seico Benner. and William {B. Dunbar}.},
title={RAPID FINITE STATE MACHINE CONTROL OF INDIVIDUAL DNA MOLECULES IN A NANOPORE},
booktitle={Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 2: BIODEVICES},
year={2008},
pages={93-98},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001053000930098},
isbn={978-989-8111- 17-3},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 2: BIODEVICES
TI - RAPID FINITE STATE MACHINE CONTROL OF INDIVIDUAL DNA MOLECULES IN A NANOPORE
SN - 978-989-8111- 17-3
IS - 2184-4305
AU - A. Wilson, N.
AU - Abu-Shumays, R.
AU - Koch, E.
AU - Benner, S.
AU - B. Dunbar, W.
PY - 2008
SP - 93
EP - 98
DO - 10.5220/0001053000930098
PB - SciTePress

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