Authors:
Sulaiman Yusuf
1
;
Yati Soenarto
2
;
Muhammad Juffrie
2
;
Wiryatun Lestariana
3
and
Mudatsir
4
Affiliations:
1
Department of Paediatric Medical Faculty Syiah Kuala University, Banda Aceh, Indonesia
;
2
Department of Paediatric Medical Faculty Gadjah Mada University, Yogyakarta, Indonesia, Indonesia
;
3
Department of Biochemistry Medical Faculty Gadjah Mada University, Yogyakarta, Indonesia, Indonesia
;
4
Department of Microbiology Medical Faculty Syiah Kuala University, Aceh, Indonesia, Indonesia
Keyword(s):
Zinc, Escherichia Coli, Diarrhea
Abstract:
The level of zinc requirements will increase due to infection, for formation of immune function and new cells. The advantage of Zinc is maintain the integrity of the intestinal mucosa through its function in cell regeneration and membrane stability. The aim of this study is to determine the level of zinc serum after oral zinc on mice diarrheal induce E.Coli-LPS. This study used a controlled trial experimental design in the laboratory. Sample of 20 mice were randomly divided into 4 groups:1). Control group was given standard foods, 2). Trial group was given E.Coli-LPS 2.5 mg/kg/oral once on day-1, 3). Preventive group was given E.Coli-LPS once 2.5 mg/kg/oral once on day-1 + 30 mg/kg/oral of zinc once daily for 12 days. 4). Therapy group was given E.Coli-LPS 2.5 mg/kg/oral once on day-1, if diarrheal was given 30 mg/kg/oral of zinc once daily for 12 days. Blood samples of mice were taken through the orbital sinus on the 0, 5th, 10thhour, 4th, 8th and 12thday. Data are presented in tabl
es and graphic. We found that higher levels of zinc in the preventive and therapy group especially on 4th, 8th and 12th day. I conclusion, oral administration of zinc increase serum zinc levels, especially in control and experimental groups.
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