PRECLINICAL TESTING OF A NEW VENOUS VALVE

Laura-Lee Farrell; David N. Ku

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Paper

PRECLINICAL TESTING OF A NEW VENOUS VALVE

Topics: Biomechanical Devices; Technologies Evaluation

In Proceedings of the First International Conference on Biomedical Electronics and Devices - Volume 1: BIODEVICES, 30-35, 2008 , Funchal, Madeira, Portugal

Authors: Laura-Lee Farrell and David N. Ku

Affiliation: Georgia Institute of Technology, United States

Keyword(s): Vein, venous valves, thrombosis, patency.

Related Ontology Subjects/Areas/Topics: Biomechanical Devices ; Biomedical Engineering ; Biomedical Instruments and Devices ; Technologies Evaluation

Abstract: Venous valvular incompetency is a debilitating disease affecting millions of patients. Unfortunately, the current physiologic and surgical treatments are prone to the extreme risk of post-operative thrombosis. A new design for venous valves has been proposed using biomimicry. The medical device has the shape of a natural valve with sufficient elasticity to maintain patency and competency in the leg veins. The venous valve was tested for patency, competency, cyclic fatigue, compressibility, and thrombogenicity. Patency is maintained with a low opening pressure of less than 3 mmHg. Competency is maintained with backpressures exceeding 300 mmHg. The valve is fatigue resistant to over ¼ million cycles. The valve can maintain its integrity when compressed in a stent and deployed without tilting or mal-alignment. Little thrombus forms on the valve with perfusion of whole blood under pulsatile flow conditions. The pre- clinical tests demonstrate efficacy as a new venous valve for treatment of chronic venous insufficiency. (More)

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Paper citation in several formats:

Farrell, L. and N. Ku, D. (2008). PRECLINICAL TESTING OF A NEW VENOUS VALVE. In Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 1: BIODEVICES; ISBN 978-989-8111- 17-3; ISSN 2184-4305, SciTePress, pages 30-35. DOI: 10.5220/0001050000300035

@conference{biodevices08,
author={Laura{-}Lee Farrell. and David {N. Ku}.},
title={PRECLINICAL TESTING OF A NEW VENOUS VALVE},
booktitle={Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 1: BIODEVICES},
year={2008},
pages={30-35},
publisher={SciTePress},
organization={INSTICC},
doi={10.5220/0001050000300035},
isbn={978-989-8111- 17-3},
issn={2184-4305},
}

TY - CONF

JO - Proceedings of the First International Conference on Biomedical Electronics and Devices (BIOSTEC 2008) - Volume 1: BIODEVICES
TI - PRECLINICAL TESTING OF A NEW VENOUS VALVE
SN - 978-989-8111- 17-3
IS - 2184-4305
AU - Farrell, L.
AU - N. Ku, D.
PY - 2008
SP - 30
EP - 35
DO - 10.5220/0001050000300035
PB - SciTePress